Bioorganic and Medicinal Chemistry Letters p. 1833 - 1836 (1997)
Update date:2022-07-29
Topics:
Sodeoka, Mikiko
Baba, Yoshiyasu
Kobayashi, Satoko
Hirukawa, Nozomu
The effects of structural modification of cantharidin on the inhibition of protein Ser/Thr phosphatases are described. Removal of the methyl substituents at C2 and C3 in cantharidin improved the inhibition of PP2B. In contrast, introduction of a substituent to C1/C4-position drastically decreased inhibition of PP1 and PP2A1. PP2B was found to be quite tolerant to modifications at the C5 position.
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