Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles

DOI: 10.1055/s-0040-1707321

Source and publish data:

Synlett p. 86 - 90 (2021)

Update date:2022-08-03

Topics:

Authors:

Qiu, Shanguang

Chen, Yuxue

Song, Xinming

Liu, Li Liu, Li

Liu, Xi Liu, Xi

Wu, Luyong

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Article abstract of DOI:10.1055/s-0040-1707321

Intermolecular cycloaddition of tosylhydrazones with nitriles was investigated. t -BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol, and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H -1,2,3-triazoles were prepared in good to excellent yields and with high purities. The process is azide-free and transition-metal-free.

Full text of DOI:10.1055/s-0040-1707321

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