Tetrahedron Letters p. 8221 - 8224 (1998)
Update date:2022-08-03
Topics:
Sun, Jerry S.
Geiser, Andrew H.
Frydman, Benjamin
The lithium salt of 2-hydroxy-1,4-naphthoquinone was prepared in situ by addition of lithium hydride to the frozen solution of the quinone in dimethyl sulfoxide. As the solution thawed, the lithium quinone was slowly formed and was then alkylated with 3,3-dimethylallyl bromide. Lapachol was thus obtained in 40% yield. When treated with m-chloroperoxybenzoic acid it was converted into its epoxide, that was cyclized with boron trifluoride etherate to 3- hydroxy-β-lapachone in 67% overall yield. Esters of the latter were prepared by condensation with carboxylic acid derivatives using 1,1 '- carbonyldiimidazole and DBU as condensing agents.
View MoreTengzhou Runlong Fragrance Co., Ltd.
website:http://www.tzrunlong.com/
Contact:0086-15665710862
Address:No. 78, Fushan Road, Biomedical Industrial Park, Dawu Town, Tengzhou, Shandong, 277514 China
Hubei Xiangxi Chemical Industry Co.,Ltd
Contact:+86-710-3454830
Address:No.7, Daqing East Road, Xiangfan City, Hubei Province, China
Liao Cheng All Win Chemicals Co.,LTD
Contact:86+0635-2991582
Address:Room 402,Unit 1,No.27 building.Zhong tong shi dai haoyuan,liaocheng city,Shan dong Province.China
Contact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Tianjin Boron PharmaTech Co.,Ltd.(expird)
Contact:86-022-59845187
Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China
Doi:10.1002/jms.1889
(2011)Doi:10.1016/j.dyepig.2020.108726
(2021)Doi:10.1021/jo01257a081
(1969)Doi:10.1016/S0040-4020(97)00722-9
(1997)Doi:10.1055/s-1997-1277
(1997)Doi:10.1021/jo970712g
(1997)