Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog

DOI: 10.1016/S0960-894X(98)00641-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3495 - 3498 (1998)

Update date:2022-08-02

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Authors:

Iwama, Seiji

Segawa, Masaki

Fujii, Shinobu

Ikeda, Kiyoshi

Katsumura, Shigeo

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Article abstract of DOI:10.1016/S0960-894X(98)00641-6

All stereoisomers of N-acyl-4,5-disubstituted oxazolidinone phospholipid analogs were synthesized by regio and stereoselective epoxide ring opening accompanied by introduction of an amino group. The (4R,5S)-derivative showed stronger inhibitory activity toward type II phospholipase A₂ than the 4- substituted oxazolidinone phospholipid analog previously reported.

Full text of DOI:10.1016/S0960-894X(98)00641-6

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