Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog

Article abstract of DOI:10.1016/S0960-894X(98)00641-6

All stereoisomers of N-acyl-4,5-disubstituted oxazolidinone phospholipid analogs were synthesized by regio and stereoselective epoxide ring opening accompanied by introduction of an amino group. The (4R,5S)-derivative showed stronger inhibitory activity toward type II phospholipase A₂ than the 4- substituted oxazolidinone phospholipid analog previously reported.