Bioorganic and Medicinal Chemistry Letters p. 3495 - 3498 (1998)
Update date:2022-08-02
Topics:
Iwama, Seiji
Segawa, Masaki
Fujii, Shinobu
Ikeda, Kiyoshi
Katsumura, Shigeo
All stereoisomers of N-acyl-4,5-disubstituted oxazolidinone phospholipid analogs were synthesized by regio and stereoselective epoxide ring opening accompanied by introduction of an amino group. The (4R,5S)-derivative showed stronger inhibitory activity toward type II phospholipase A2 than the 4- substituted oxazolidinone phospholipid analog previously reported.
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