Conjugate addition of nitrogen nucleophiles to an α,β-unsaturated pyrrolidinone

DOI: 10.1016/S0040-4039(97)01312-9

Source and publish data:

Tetrahedron Letters p. 5891 - 5894 (1997)

Update date:2022-08-05

Topics:

Authors:

Chan, Philip W. H.

Cottrell, Ian F.

Moloney, Mark G.

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Article abstract of DOI:10.1016/S0040-4039(97)01312-9

The conjugate addition of nitrogen nucleophiles to α,β-unsaturated lactam 1b under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to β-aminopyrrolidinones in excellent overall yield.

Full text of DOI:10.1016/S0040-4039(97)01312-9

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