Conjugate addition of nitrogen nucleophiles to an α,β-unsaturated pyrrolidinone

Article abstract of DOI:10.1016/S0040-4039(97)01312-9

The conjugate addition of nitrogen nucleophiles to α,β-unsaturated lactam 1b under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to β-aminopyrrolidinones in excellent overall yield.