Ring transformation of fused pyridazines. VI. Construction of 3-(2-pyridyl)indole skeleton by means of N-N bond cleavage reaction of fused pyridazines with ynamines

Article abstract of DOI:10.3987/COM-97-7847

We established a new N-N bond cleavage reaction of pyridazino[4,5-b]indoles with ynamines to form 3-(2-pyridyl)indoles. The latter are easily converted to 3-(2-piperidyl)indoles, which are key intermediates for the synthesis of indole alkaloids.