Chiral azacrown ethers derived from D-glucose as catalysts for enantioselective Michael addition

Article abstract of DOI:10.1016/S0040-4039(97)01686-9

Chiral monoaza-crown ethers incorporating glucose units have been synthesized and applied as phase transfer catalysts in the enantioselective Michael addition of 2-nitropropane to a chalcone to give the corresponding adduct in enantiomeric excess up to 90%.