Bioorganic and Medicinal Chemistry Letters p. 1979 - 1984 (1997)
Update date:2022-08-02
Topics:
Bigge, Christopher F.
Yi, C. Stephen
Nordblom, Gerald D.
A nine-step synthesis of N-desmethyl PNQX 5 and its subsequent elaboration into analogs, a porcine thyroglobulin immunogenic conjugate 8, and a radioiodinated analyte 10 are described. These compounds were used for the development of a specific radioimmunoassay for PNQX, a potent neuroprotective agent with mixed AMPA/NMDA glycine site antagonist activity.
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