Synthesis of 2-O-Fucosyl Sulfatide, a Blocker of L- and P-Selectin

Article abstract of DOI:10.1271/bbb.61.1615

A new derivative of sulfatide, 2-O-α-L-fucopyranosyl sulfatide, was synthesized. The compound inhibited the binding of HL-60 cells, which express sialyl Lewis X, to P- and L-selectin more than the corresponding non fucosylated compound.

Full text of DOI:10.1271/bbb.61.1615

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Bioscience, Biotechnology, and Biochemistry
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Synthesis of 2-O-Fucosyl Sulfatide, a Blocker of L-
and P-Selectin
Hideharu Ishidaa, Satoshi Sagoa, Takao Ikamiab, Makoto Kisoa & Akira Hasegawaa
a Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501–11, Japan
b Drug Discovery Research Department, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki,
Hokusei-cho, Mie 511–04, Japan
Published online: 12 Jun 2014.
To cite this article: Hideharu Ishida, Satoshi Sago, Takao Ikami, Makoto Kiso & Akira Hasegawa (1997) Synthesis of 2-
O-Fucosyl Sulfatide, a Blocker of L- and P-Selectin, Bioscience, Biotechnology, and Biochemistry, 61:9, 1615-1616, DOI:
10.1271/bbb.61.1615
To link to this article: http://dx.doi.org/10.1271/bbb.61.1615
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