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Membrane-permeant esters of inositol polyphosphates, chemical syntheses and biological applications

DOI: 10.1016/S0040-4020(97)00714-X

Source and publish data:

Tetrahedron p. 12017 - 12040 (1997)

Update date:2022-08-03

Topics:

Authors:

Li, WenhongLi, Wenhong

Schultz, CarstenSchultz, Carsten

Llopis, JuanLlopis, Juan

Tsien, Roger Y.Tsien, Roger Y.

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Article abstract of DOI:10.1016/S0040-4020(97)00714-X

Membrane-permeant derivatives of inositol polyphosphates are useful tools for biological studies. Racemic 2,3,6-tri-O-butyryl-myo-inositol 1,4,5-trisphosphate hexakis(acetoxymethyl) ester(Bt3IP3/AM), myo-inositol 1,4,5-trisphosphate hexakis(acetoxymethyl) ester (IP3/AM), hexakis(propionyloxymethyl) ester (IP3/PM) and hexakis(butyryloxymethyl) ester (IP3/BM) were therefore synthesized. Whereas extracellular application of up to 200 μM of Bt3IP3/AM or IP3/AM to 1321N1 astrocytoma cells failed to mobilize internal calcium, IP3/PM and IP3/BM released internal calcium at concentrations as low os 20 μM and 2 μM, respectively.

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Full text of DOI:10.1016/S0040-4020(97)00714-X

Products guided by the article

Product name:Phosphoric acid bis-(2-cyano-ethyl) ester 2,4,6-tris-benzyloxy-3,5-bis-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester

Cas No:196954-70-8

196954-70-8

R&D Labs maybe for 196954-70-8

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