Tetrahedron p. 12017 - 12040 (1997)
Update date:2022-08-03
Topics:
Li, Wenhong
Schultz, Carsten
Llopis, Juan
Tsien, Roger Y.
Membrane-permeant derivatives of inositol polyphosphates are useful tools for biological studies. Racemic 2,3,6-tri-O-butyryl-myo-inositol 1,4,5-trisphosphate hexakis(acetoxymethyl) ester(Bt3IP3/AM), myo-inositol 1,4,5-trisphosphate hexakis(acetoxymethyl) ester (IP3/AM), hexakis(propionyloxymethyl) ester (IP3/PM) and hexakis(butyryloxymethyl) ester (IP3/BM) were therefore synthesized. Whereas extracellular application of up to 200 μM of Bt3IP3/AM or IP3/AM to 1321N1 astrocytoma cells failed to mobilize internal calcium, IP3/PM and IP3/BM released internal calcium at concentrations as low os 20 μM and 2 μM, respectively.
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Doi:10.1016/S0040-4039(97)01759-0
(1997)Doi:10.1021/jo962092+
(1997)Doi:10.1039/a703059b
(1997)Doi:10.1016/S0040-4020(97)00988-5
(1997)Doi:10.1007/BF02495925
(1997)Doi:10.1016/S0040-4039(97)10067-3
(1997)
