Synthesis of (2S,3R,4S)-3,4-methanoproline and analogues by cyclopropylidene insertion

Article abstract of DOI:10.1016/S0040-4020(97)00988-5

Intramolecular insertion of single enantiomers of cyclopropylidenes into 5,6-related C-H bonds adjacent to nitrogen has been used to obtain enantiomerically pure methanoproline and a number of analogues with a high degree of one- or two-fold asymmetric induction.