Efficient synthesis of ganglioside GM2 for use in cancer vaccines

DOI: 10.1002/anie.199719981

Source and publish data:

Angewandte Chemie - International Edition in English p. 1998 - 2001 (1997)

Update date:2022-09-26

Topics:

Authors:

Castro-Palomino

Ritter Ritter

Fortunato

Reinhardt

Old Old

Schmidt Schmidt

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Article abstract of DOI:10.1002/anie.199719981

A target antigen for cancer immunotherapy, ganglioside GM2, is expressed on the cell surface of several human cancer types. An efficient chemical synthesis can now make available ample amounts of a structurally well-defined synthetic GM2, free of biological contaminants. This greatly facilitates the systematic construction of safe and efficient GM2 cancer vaccines.

Full text of DOI:10.1002/anie.199719981

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