Synthesis of silicon-containing α-amino acids and hydantoins

Article abstract of DOI:10.1016/S0040-4020(97)00887-9

Three new silicon containing α-amino acids 6a-c and their respective hydantoin derivatives 8a-c have been prepared in racemic form. Alkylation of an α-amino cyanoacetate derivative with iodomethyl-substituted silanes, followed by hydrolysis gave the amino acids, and the subsequent reactions with KOCN and with HCl gave the hydantoins. The hydantoins are planned to be subjected to a biotechnological deracemization process.