Design and synthesis of sialyl Le(x) mimetics based on carbocyclic scaffolds derived from (-)-quinic acid

DOI: 10.1016/S0960-894X(97)10077-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2729 - 2734 (1997)

Update date:2022-08-04

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Authors:

Hanessian, Stephen

Reddy, Gurijala V.

Huynh, Hoan K.

Jingwen, Pan

Pedatella, Silvana

Ernst, Beat

Kolb, Hartmuth C.

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Article abstract of DOI:10.1016/S0960-894X(97)10077-4

The synthesis of sialyl Lewis(x) mimetic analogs in which the D-glucosamine, D-galactose, and sialic acid residues are replaced individually with appropriate glycomimetics is described. A computational model for predicting bioactive conformations was test

Full text of DOI:10.1016/S0960-894X(97)10077-4

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Product name:2,2-Dimethyl-propionic acid (2R,3S,4S,5R,6R)-3,4,5-triacetoxy-6-[(1R,2R,3R,5S)-5-(2,2-dimethyl-propionyloxymethyl)-2,3,5-trihydroxy-cyclohexyloxy]-tetrahydro-pyran-2-ylmethyl ester

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