Bioorganic and Medicinal Chemistry Letters p. 2657 - 2660 (1997)
Update date:2022-08-03
Topics:
Nishikawa, Asuka
Shirai, Ryuichi
Koiso, Yukiko
Hashimoto, Yuichi
Iwasaki, Shigeo
A series of side chain-modified analogs of curacin A, a powerful antimitotic agent isolated from a Caribbean cyanobacterium was synthesized and the effect of these compounds on in vitro microtubule polymerization was examined. The analogs showed weak or no anti-tubulin activity, suggesting that the whole side chain structure of curacin A is required for the interaction with tubulin.
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