Tetrahedron p. 15787 - 15798 (1997)
Update date:2022-07-30
Topics:
Bowman, W. Russell
Coghlan, Daniel R.
Monoalkylation of the α-amino group of α-amino acid derivatives can be facilitated using 2 -and 4-nitrophenylsulfonamide intermediates. The nitrophenylsulfonamides of α-amino esters can be alkylated using an equimolar amount of carbonate base and a variety of alkyl bromides. Ready removal of the nitrophenylsulfonyl group is facilitated by S(N)Ar reaction between the N-alkylated sulfonamide and phenylthiolate to give the N-alkylated α-amino esters in good yield without racemisation of the chiral α-centres.
View MoreShenzhen Sunrising Industry Co., ltd.
Contact:+86 755 86571158 / 86571159 / 86571160
Address:2108 ZHENYE INT. BUSINESS CENTER,NO.3101-90 QIANHAI RD, NANSHAN,SHENZHEN, CHINA
Shanghai Potomer International Trade CO., LTD
Contact:+86-21-61397128
Address:Room 304,No.505 ,Caoyang Road.Shanghai,China
Contact:+86-27-85733560
Address:NO.308,QINGNIAN RD.,WUHAN,CHINA
Antaeus Bio-technology Co., LTD(expird)
Contact:021-31252569
Address:shanghai pudong
Nanjing Capatue Chemical Co., Ltd
Contact:+86-25-86371192 +86-025-85720158
Address:No.20 Jiangjun Avenue, Jiangning Economic & Technical Development Zone
Doi:10.1021/ja0399122
(2004)Doi:10.1021/jo01323a020
(1979)Doi:10.1039/b814374a
(2008)Doi:10.1002/hlca.19780610812
(1978)Doi:10.1007/s13361-015-1171-5
(2015)Doi:10.1016/j.bmcl.2013.07.047
(2013)