An efficient synthesis of 6-substituted 2-(2H-[1,2,4]triazol-3- ylmethyl)-1,2,3,4-tetrahydro-isoquinolines

Article abstract of DOI:10.1080/00397919908085813

A synthesis of 6-nitro and 6-amino 2-(2H-[1,2,4]triazol-3- ylmethyl)1,2,3,4-tetrahydro-isoquinolines using a bis-alkylation process is described. 5-(Aminomethyl)-1-(p-methoxybenzyl)-triazole was prepared by a regioselective route from 1,2,4-triazole.

Full text of DOI:10.1080/00397919908085813

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Synthetic Communications: An
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An Efficient Synthesis
Of 6-Substituted 2-
(2H-[1,2,4]Triazol-3-
Ylmethyl)-1,2,3,4-Tetrahydro-
Isoquinolines
Frank J. Urban a & Ralph Breitenbach a
a Pfizer Inc, Central Research Division Process
Research and Development , Eastern Point Rd.,
Groton, CT, 06340
Published online: 17 Sep 2007.
To cite this article: Frank J. Urban & Ralph Breitenbach (1999) An Efficient Synthesis
Of 6-Substituted 2-(2H-[1,2,4]Triazol-3-Ylmethyl)-1,2,3,4-Tetrahydro-Isoquinolines,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 29:4, 645-653, DOI: 10.1080/00397919908085813
To link to this article: http://dx.doi.org/10.1080/00397919908085813
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