Adenosine-5'-carboxaldehyde: A potent inhibitor of S-adenosyl-L- homocysteine hydrolase

DOI: 10.1021/jm00059a013

Source and publish data:

Journal of Medicinal Chemistry p. 883 - 887 (1993)

Update date:2022-07-30

Topics:

Authors:

Liu Liu

Wnuk Wnuk

Yuan Yuan

Robins Robins

Borchardt

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Article abstract of DOI:10.1021/jm00059a013

Adenosine-5'-carboxaldehyde (3) and its 4'-epimer (4) were synthesized and shown to be potent type I mechanism-based inhibitors of recombinant rat liver AdoHcy hydrolase with k₂/K₁ values of 16.7 x 10^-3 and 5.5 x 10^-3

Full text of DOI:10.1021/jm00059a013

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