Stereocontrolled synthesis of enantiopure substituted 4-aminopyrrolidin-2-ones

DOI: 10.1016/S0040-4039(97)10216-7

Source and publish data:

Tetrahedron Letters p. 8037 - 8040 (1997)

Update date:2022-07-31

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Authors:

Langlois, Nicole

Calvez, Olivier

Radom, Marie-Odile

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Article abstract of DOI:10.1016/S0040-4039(97)10216-7

The highly diastereoselective conjugate addition of N-benzylhydroxylamine and benzylamine to α,β-unsaturated lactam 3 provided an efficient entry to enantiopure (4S,5S)-4-amino-5-hydroxymethylpyrrolidin-2-ones.

Full text of DOI:10.1016/S0040-4039(97)10216-7

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Product name:(2S,3S)-3-(Benzyl-hydroxy-amino)-2-(1-ethoxy-ethoxymethyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

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