Utilization of the ArH-PCl3-AlCl3 Reaction Product as the Source of Phosphorus in the Phosphetane Synthesis of McBride, et al.

Article abstract of DOI:10.1055/s-1987-27910

A variation of the phosphetane 1-oxide synthesis of McBride, et al., is described, in which, instead of arylphosphonous dihalide, the in situ reaction of arenes with phosphorus trichloride-aluminum trichloride is used in a one-pot approach.Reaction of the complex formed with 3,3-dimethyl-1-butene or 2,4,4-trimethyl-2-pentene results in the formation of cis/trans mixtures of 1-aryl-2,2,3-trimethylphosphetane 1-oxides or 1-aryl-2,2,3,4,4-pentamethylphosphetane 1-oxides, respectively, in which the trans isomer predominates.