Stereoselective inhibition of human butyrylcholinesterase by phosphonothiolate analogs of (+)- and (-)-cocaine

DOI: 10.1016/S0006-2952(97)00403-6

Source and publish data:

Biochemical Pharmacology p. 1261 - 1266 (1997)

Update date:2022-08-03

Topics:

Authors:

Berkman, Clifford E.

Underiner, Gail E.

Cashman, John R.

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Article abstract of DOI:10.1016/S0006-2952(97)00403-6

The hydrolysis of cocaine (benzoylecgonine methyl ester) to ecgonine methyl ester by human butyrylcholinesterase (BuChE; EC 3.1.1.8) has been shown previously to constitute an important means to detoxicate this material to pharmacologically inactive metab

Full text of DOI:10.1016/S0006-2952(97)00403-6

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