Synthesis of N-acetyl derivatives of 5- and 6-ethoxy-2-methylthiobenzimidazole and their cardiotonic activity

Article abstract of DOI:10.1007/BF02291796

The regioselectivity of the N-acetylation of 5- and 6-ethoxy-2-methylthiobenzimidazole for various acetylating agents under various conditions has been investigated. The cardiotonic activity of the 1-acetyl-5-ethoxy- and 1-acetyl-6-ethoxy-2-methylthiobenzimidazoles synthesized and of their 5,6-diethoxy analog has been studied. 1997 Plenum Publishing Corporation.