Enantioselective α-alkylation of piperidine via chiral perhydropyrido [2,1-b] [1,3,4]-oxadiazinone: An easy route for the synthesis of both enantiomers of coniine

Article abstract of DOI:10.1016/S0040-4039(97)10438-5

Enantioselective direct alkylation of piperidine involving chiral perhydropyrido [2,1-b] [1,3,4]-oxadiazinone using either form of mandelic acid as chiral auxiliary is reported. The application of the strategy is demonstrated by the synthesis of(R)- as well as (S)- coniine.