Fischer indolization of 2-sulfonyloxyphenylhydrazones: A new and practical approach for preparing 7-oxygenated indoles and application to the first synthesis of eudistomidin-A. (Fischer indolization and its related compounds. Part 28)

DOI: 10.1016/S0040-4020(97)10255-1

Source and publish data:

Tetrahedron p. 45 - 64 (1998)

Update date:2022-07-31

Topics:

Authors:

Murakami, Yasuoki

Watanabe, Toshiko

Takahashi, Hiroyuki

Yokoo, Hiroshi

Nakazawa, Yoshie

Koshimizu, Michie

Adachi, Nori

Kurita, Masami

Yoshino, Tomoko

Inagaki, Takayuki

Ohishi, Maki

Watanabe, Mari

Tani, Masanobu

Yokoyama, Yuusaku

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Article abstract of DOI:10.1016/S0040-4020(97)10255-1

An efficient method for synthesis of 7-oxygenated indoles was established by Fischer indolization of the phenylhydrazones (10) with a sulfonyloxy group at the ortho-position. This method was applied to the first synthesis of the calmodulin antagonist eudistomidin-A (2).

Full text of DOI:10.1016/S0040-4020(97)10255-1

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