Synthesis p. 1411 - 1414 (1997)
Update date:2022-07-31
Topics:
Kowalczyk, Bruce A.
A simple synthetic strategy to dihalophenylacetic acids and specifically 3,5-difluorophenylacetic acid an important pharmaceutical intermediate was developed. The aromatic nucleophilic substitution of dihalofluorobenzenes using the anion of ethyl cyanoacetate yielded ethyl dihalophenylcyanoacetates. The basic decarboxylation of the ethyl dihalophenylcyanoacetates produced targeted dihalophenylacetic acids.
View MoreContact:0571-
Address:zhejing
Linyi Shengxin Pharmaceutical R&D Co., Ltd
Contact:+86-18653953873
Address:West First of Yufeng Road, Yishui County
Contact:+86-371-86058576
Address:NO.32, Jingsan Road, Zhengzhou, China
Jiangsu Cale New Material Co.ltd
Contact:+86-515-88334667/88203550
Address:Zhongshan 3rd Road, Coastal Chemical Industry Park, Yancheng, Jiangsu, China
Liaoyang hengye Chemical Co., Ltd.
Contact:86-419-5850866
Address:North Old Xiaoxiao Road,Yantai District, Dengta, Liaoyang, Liaoning, China
Doi:10.1007/BF02495774
(2000)Doi:10.1016/j.bmc.2015.07.071
(2015)Doi:10.1246/bcsj.71.433
(1998)Doi:10.1021/jo9716845
(1998)Doi:10.1248/cpb.46.79
(1998)Doi:10.1002/(sici)1521-3749(199803)624:3<399::aid-zaac399>3.0.co;2-7
(1998)
