Synthesis p. 1411 - 1414 (1997)
Update date:2022-07-31
Topics:
Kowalczyk, Bruce A.
A simple synthetic strategy to dihalophenylacetic acids and specifically 3,5-difluorophenylacetic acid an important pharmaceutical intermediate was developed. The aromatic nucleophilic substitution of dihalofluorobenzenes using the anion of ethyl cyanoacetate yielded ethyl dihalophenylcyanoacetates. The basic decarboxylation of the ethyl dihalophenylcyanoacetates produced targeted dihalophenylacetic acids.
View MoreJiaozuo Zhongwen Trading Coporation Limited
Contact:--
Address:East Renmin Road
AllyChem Co., Ltd., Dalian, China（BBChem）
Contact:+86-411-62313318/62313328
Address:No.5 of Jinbin Road, Jinzhou New District, Dalian City, Liaoning Province, P.R.China
ShanDong XinDa Chemical CO.,LTD(expird)
Contact:086-0311-87580543
Address:No.168, High Technology Development Zone Jinan Shandong China
hangzhou verychem science and technology co.ltd
website:http://www.verypharm.com
Contact:+86-571-88162785; 88162786
Address:F1502, 753 Shenhua road, Hangzhou, China
Shenyang Mole pharmaceutical Technology Development Co.,Ltd
Contact:+86-24-31204918/13889278616
Address:No.44, wanliutang road, shenhe District of Shenyang
Doi:10.1007/BF02495774
(2000)Doi:10.1016/j.bmc.2015.07.071
(2015)Doi:10.1246/bcsj.71.433
(1998)Doi:10.1021/jo9716845
(1998)Doi:10.1248/cpb.46.79
(1998)Doi:10.1002/(sici)1521-3749(199803)624:3<399::aid-zaac399>3.0.co;2-7
(1998)
