Tetrahedron Letters p. 229 - 232 (1998)
Update date:2022-07-29
Topics:
Baker, Robert K.
Rupprecht, Kathleen M.
Armistead, David M.
Boger, Joshua
Frankshun, Robert A.
Hodges, Paul J.
Hoogsteen, Karst
Pisano, Judith M.
Witzel, Bruce E.
The C28-C32 cyclohexyl group of the natural product, FK-506, was prepared enantioselectively from the iodolactone by replacement of iodide with retention of configuration. The C27-C28 trisubstituted olefin was introduced stereoselectively via a classical aldol/elimination sequence employing titanium enolate methodology. Elaboration of this chemistry has led to a synthesis of a C22-C34 fragment of the natural product.
View MoreJIN TAN CHENG'EN CHEMICAL CO.,LTD.
Contact:86-519-82116250
Address:NO.102，village Dongfang，conomic development zone
Chengdu CSH Pharmaceutical Co.,ltd
Contact:+86-(28)-85321971
Address:Block B,New Hope Int. Tian Fu New District, Chengdu, Sichuan, China
Contact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Contact:+86-515-88356562
Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
LIAONING DMSO CHEMICALS CO.,LTD.
website:http://www.chinadmso.com
Contact:+86-427-6503033
Address:FLOOR 16, BLOCK A, FINANCIAL SQUARE, XINGLONGTAI DISTRICT, PANJIN CITY, LIAONING P.R. CHINA
Doi:10.1016/S0040-4039(97)10743-2
(1998)Doi:10.1021/ja9739796
(1998)Doi:10.1021/jo900205x
(2009)Doi:10.1021/ja973150r
(1998)Doi:10.1021/jo00376a085
(1986)Doi:10.1016/0040-4039(96)01810-2
(1996)
