Oligonucleotide analogues with 4-hydroxy-N-acetylprolinol as sugar substitute

DOI: 10.1002/chem.19970031215

Source and publish data:

Chemistry - A European Journal p. 1997 - 2010 (1997)

Update date:2022-08-04

Topics:

Authors:

Ceulemans, Griet

Van Aerschot, Arthur

Wroblowski, Berthold

Rozenski, Jef

Hendrix, Chris

Herdewijn, Piet

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Article abstract of DOI:10.1002/chem.19970031215

Modified oligonucleotides incorporating trans-4-hydroxy-N-acetyl-L-prolinol (trans-4-HO-L-NAP) or its D-analogue as sugar substitute were synthesised with adenine and thymine as nucleobases. All-adenine oligonucleotides built from (2S,4S) or (2R,4R)-cis-4

Full text of DOI:10.1002/chem.19970031215

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