
Tetrahedron Letters p. 803 - 806 (1998)
Update date:2022-08-04
Topics:
Mulzer, Johann
Berger, Markus
An efficient synthesis of the protected seco acid 2 of the antibiotic macrodiolide tartrolon 1 is described. Key steps are a substrate controlled aldol-reaction, a Johnson-Claisen rearrangement, and a Horner-Wadsworth-Emmons olefination with subsequent Co
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