Studies directed towards the total synthesis of the antibiotic macrodiolide tartrolon: EPC synthesis of the protected seco acid

DOI: 10.1016/S0040-4039(97)10761-4

Source and publish data:

Tetrahedron Letters p. 803 - 806 (1998)

Update date:2022-08-04

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Authors:

Mulzer, Johann

Berger, Markus

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Article abstract of DOI:10.1016/S0040-4039(97)10761-4

An efficient synthesis of the protected seco acid 2 of the antibiotic macrodiolide tartrolon 1 is described. Key steps are a substrate controlled aldol-reaction, a Johnson-Claisen rearrangement, and a Horner-Wadsworth-Emmons olefination with subsequent Co

Full text of DOI:10.1016/S0040-4039(97)10761-4

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