Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Article abstract of DOI:10.1016/S0960-894X(99)00250-4

Thalidomide, (1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC. Herein we describe the TNF-α inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-α release in LPS stimulated human PBMC.