Synthesis of 3′-azido, 2′,3′-didehydro, and 3′,4′-didehydro nucleosides from 5-alkoxymethyluracils

Article abstract of DOI:10.1007/PL00010110

Reaction of methyl 5-tert-butyldiphenylsilyl-2,3-dideoxy-3-iodo-D-threo-pentofuranoside (3) with silylated 5-alkoxymethyluracils 2a-c using trimethylsilyl trifluoromethanesulfonate as a catalyst afforded the α nucleosides 4a-c and the β nucleosides 5a-c.