Synthesis of Ethynyl-Substituted Quinquephenyls and Conversion to Extended Fused-Ring Structures

Article abstract of DOI:10.1021/jo9721251

An organometallic coupling, electrophile-induced cyclization strategy for the synthesis ofp-terphenyl compounds has been extended to the synthesis of p-quinquephenyl systems. In this work we report the synthesis of various polycyclic aromatic systems containing nine annelated rings including the synthesis of functionalized polycyclic aromatic systems. An interesting side reaction which leads to an indenyl spiro ring system is also described. This side reaction can be suppressed by changing the electrophile (from H⁺ to I⁺) or by modification of the cyclization precursor. The UV-vis and fluorescence spectra of several of these polycyclic aromatics and the p-quinquephenyl precursors are also reported.

Full text of DOI:10.1021/jo9721251

1676
J . Org. Chem. 1998, 63, 1676-1686
Syn th esis of Eth yn yl-Su bstitu ted Qu in qu ep h en yls a n d Con ver sion
to Exten d ed F u sed -Rin g Str u ctu r es†
Marc B. Goldfinger,‡ Khushrav B. Crawford,§ and Timothy M. Swager*,§
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue,
Cambridge, Massachusetts 02139, and Department of Chemistry, University of Pennsylvania,
Philadelphia, Pennsylvania 19104
Received November 19, 1997
An organometallic coupling, electrophile-induced cyclization strategy for the synthesis of p-terphenyl
compounds has been extended to the synthesis of p-quinquephenyl systems. In this work we report
the synthesis of various polycyclic aromatic systems containing nine annelated rings including the
synthesis of functionalized polycyclic aromatic systems. An interesting side reaction which leads
to an indenyl spiro ring system is also described. This side reaction can be suppressed by changing
the electrophile (from H+ to I+) or by modification of the cyclization precursor. The UV-vis and
fluorescence spectra of several of these polycyclic aromatics and the p-quinquephenyl precursors
are also reported.
In tr od u ction
reaction sequence combined with the mild conditions
employed during the key ring-forming transformation
make this procedure amenable to the preparation of gram
quantities of product. This is in contrast to other
commonly employed procedures such as photochemical
cyclization6,7 or metal carbene8-13 and vinyl ketene
annulations,14-17 which require extremely dilute condi-
tions and/or multistep synthetic sequences and are
therefore amenable to the production of only limited
quantities of material. Hence, this convenient two-step
protocol serves as an attractive complement to existing
methods used for the synthesis of fused aromatics.
Extensively conjugated molecular and polymeric ma-
terials are critical components for a large number of
advanced technologies. Molecule-based sensory,1 non-
linear optical,2 photo- and electroluminescent devices,3
and photovoltaic devices4 derive function from highly
conjugated materials which can transform an applied
bias or optical input to a desired response. Future
breakthroughs in molecular electronics will be dependent
on the ability to produce conjugated structures with well-
defined geometries and functionality. This ability will
be aided by improvements in synthetic methodology
available for the synthesis of extensively conjugated
systems. One structural class of interest is the fused
polycyclic aromatics which possess planar structure and
are extensively conjugated. These systems provide a
rigid well-defined structure which does not display con-
formational uncertainities.
Recently we have described useful synthetic methodol-
ogy for the preparation of fused polycyclic aromatics.5
This method utilizes a two-step protocol wherein p-
alkoxyphenylethynyl-substituted aromatics are first pre-
pared using metal-catalyzed cross-coupling chemistries.
In the key step the ethynyl-substituted precursor com-
pound is transformed to a fused-ring system via an
electrophile-induced cyclization reaction. The reaction
may be effected with common electrophiles such as
trifluoroacetic acid (TFA) or iodonium trifluoroacetate
and proceeds under extremely mild conditions (CH2Cl2
as solvent, room temperature). This methodology has
been used to prepare benzenoid as well as benzenoid/
thiophene-containing ring systems. The high-yielding
† Part of this work was taken from the thesis of M.B.G. completed
at the University of Pennsylvania.
(6) Mallory, F. B.; Mallory, C. W. Organic Reactions; Wiley & Sons:
New York, 1984; Vol. 30.
(7) Liu, L.; Yang, B.; Katz, T. J .; Poindexter, M. K. J . Org. Chem.
1991, 56, 3769.
(8) Dotz, K. H. Angew. Chem., Intl. ed. Engl. 1984, 23, 587.
(9) Katz, T. J .; Sivavec, T. M. J . Am. Chem. Soc. 1985, 107, 737.
(10) Merlic, C. A.; Burns, E. E.; Xu, D.; Chen, S. Y. J . Am. Chem.
Soc. 1992, 114, 8722.
(11) Merlic, C. A.; Pauley, M. E. J . Am. Chem. Soc. 1996, 118, 11319.
(12) Semmelhack, M. F.; Ho, S.; Cohen, D.; Steigerwald, M.; Lee,
M. C.; Lee, G.; Gilbert, A. M.; Wulff, W. D.; Ball, R. G. J . Am. Chem.
Soc. 1994, 116, 7108.
‡ Present address: DuPont Central Research and Development,
Experimental Station, Wilmington, Delaware 19880.
§ Present address: Department of Chemistry, Massachusetts Insti-
tute of Technology, Cambridge, Massachusetts 02139.
(1) Swager, T. M.; Marsella, M. J . Adv. Mater 1994, 6, 595.
(2) Munn, R. W.; Ironside, C. N. Principles and Applications of
Nonlinear Optical Materials; Chapman & Hall: London, 1993.
(3) Greenham, N. C.; Moratti, S. C.; Bradley, D. D.; Friend, R. H.;
Holmes, A. B. Nature 1993, 365.
(4) Wrighton, M. S. Comments Inorg. Chem. 1985, 4.
(5) Goldfinger, M. B.; Crawford, K. B.; Swager, T. M. J . Am. Chem.
Soc. 1997, 119, 4578.
(13) Sivavec, T. M.; Katz, T. J .; Chiang, M. Y.; Yang, G. X.
Organometallics 1989, 8, 1620.
S0022-3263(97)02125-7 CCC: $15.00 © 1998 American Chemical Society
Published on Web 02/14/1998

Synthesis of Substituted Quinquephenyls
J . Org. Chem., Vol. 63, No. 5, 1998 1677
Ch a r t 1
Examples of compounds prepared by the electrophile-
induced cyclization reaction are depicted in Chart 1.5 To
date the majority of compounds prepared have been
substituted dibenzo[a,h]anthracene (1-6) and dibenzo-
[a,j]anthracene (7-9) ring systems. To further determine
the scope of the reaction we have examined several
additional structural variants. In one case we have
examined the ability to functionalize the iodide positions
of 2 and determine whether steric crowding will limit
functionalization of iodonium cyclized ring systems.
More important, however, we have prepared p-quin-
quephenyl precursor systems in order to prepare com-
pounds with a greater number of annelated rings than
formed in previously reported systems. Described below
are the syntheses of several p-quinquephenyl systems
and their cyclization to produce in certain cases com-
pounds containing nine annelated rings. Also described
is a side reaction which was observed and produced an
interesting indenyl spiro ring system.
F igu r e 1. Absorption (solid line) and emission (dashed line)
spectra for compounds 10 (bottom), 2 (middle), and 1 (top).
Note that 2 does not display any emission under the experi-
mental conditions due to a heavy-atom effect.
Sch em e 1
Resu lts a n d Discu ssion
As part of our efforts to investigate the scope of the
cyclization reaction we reexamined the diiodide 2. When
2 was treated with an excess of p-methoxyphenylboronic
acid under modified Suzuki cross-coupling conditions, the
product 10 was isolated in 95% yield (Scheme 1).5,18 This
result was encouraging as it demonstrated that the
dibenzo[a,h]anthracene ring systems could be highly
functionalized to yield sterically crowded products. The
effect of the added p-methoxyphenyl groups on the
dibenzo[a,h]anthracene ring system was minimal as
evidenced by the UV-vis absorption spectra (see Figure
1). Compounds 1, 2, and 10 exhibit nearly identical
absorption spectra with absorption maxima of 318, 328,
and 324 nm, respectively. The presence of low-energy
bands on the low-energy side of λmax is unchanged, with
the lowest energy transitions appearing at 430, 436, and
430 nm for 1, 2, and 10, respectively. Compound 10
displays its emission maximum at 436 nm while 1’s
emission maximum is at 438 nm.
Syn th esis of p-Qu in qu ep h en yls. The systems pre-
pared in previous studies (1-9) contain one bis(4-
alkoxyphenylethynyl)phenyl moiety which is involved in
the cyclization by electrophilic attack on the terminal
rings of the p-terphenyl moiety. To increase the number
of bis(4-alkoxyphenylethynyl)phenyl moieties to two would
require the preparation of a p-quinquephenyl ring sys-
tem. Chemoselective Suzuki cross-couplings at the iodide
positions of mixed bromide- and iodide-containing aro-
matics proved invaluable for the direct synthesis of the
functionalized p-quinquephenyl systems.
(14) Danheiser, R. L.; Casebier, D. S.; Firooznia, F. J . Org. Chem.
1995, 60, 8341.
(15) Koo, S.; Liebeskind, L. S. J . Am. Chem. Soc. 1995, 117, 3389.
(16) Sun, L.; Liebeskind, L. S. J . Org. Chem. 1995, 60, 8194.
(17) Xu, S. L.; Moore, H. W. J . Org. Chem. 1992, 57, 326.
(18) Miyaura, N.; Suzuki, A. Chem. Rev. 1995, 95, 2457.

1678 J . Org. Chem., Vol. 63, No. 5, 1998
Goldfinger et al.
Sch em e 2
The mixed iodobromide systems 12 and 12-C4 (butoxy
replaces dodecyloxy on the phenylethynyl moiety) were
prepared in yields between 80 and 85% by reaction of
the corresponding dibromides 11 with 1.15 equiv of
n-BuLi in THF followed by an I2 quench (Scheme 2). The
reaction of 12 with p-methoxyphenylboronic acid 13
provided the substituted bromobiphenyl 14 in 89% yield,
while reaction of 12-C4 with 2,5-dimethylphenylboronic
acid 20 provided the substituted bromobiphenyl 21 in
81% isolated yield. The conversion of 11 to the iodobro-
mide systems 12 was indeed necessary as reactions
employing 1:1 mixtures of its dibromide precursor and
boronic acid produced considerable amounts of the p-
terphenyl systems (confirmed by spectral comparison to
authentic samples), as the second coupling is at least as
rapid as the first coupling. In fact, the reaction of the
mixed halide 12-C4 with 1.03 equiv of 20 produced small
amounts (10-15%) of the corresponding p-terphenyl even
when the reaction temperature was lowered from 85 to
70 °C. The selectivity is higher in the synthesis of 14,
in which the presence of the electron-rich methoxy group
situated “para” to the bromide slows down the oxidative
addition of Pd(0) to the bromide.
The difficulties associated with the synthesis and puri-
fication of simple phenyldiboronic acids made the conver-
sion of the bromo biphenyls 14 and 21 to their respective
monoboronic acids 15 and 22, an operationally simpler
approach to the p-quinquephenyl systems. These boronic
acids could then be reacted with readily available aro-
matic diiodides. The p-quinquephenyl 19 was produced
in 87% yield by reaction of 15 with 1,4-diiodobenzene 17,
while the p-quinquephenyl 24 was prepared in 82%
isolated yield by reaction of 2.2 equiv of the boronic acid
22 with 2,5-diiodo-p-xylene. The three p-quinquephenyl
systems 18, 19, and 24 were obtained as colorless solids
which could be purified by standard silica gel column
chromatography (18) or crystallization (19 and 24).
The NMR spectra of these materials are straightfor-
ward and in complete agreement with the proposed
structures. The 1H NMR spectrum of 18 displays six
doublets and three singlets in the aromatic region and
triplets at 3.80 (4H) and 3.92 ppm (8H) corresponding to
the R methylene groups on the alkoxy side chains and a
singlet at 3.88 ppm representing the terminal methoxy
groups. The 13C NMR spectrum of 18 displays the
expected 21 aromatic resonances and four acetylenic
resonances. Compound 19 similarly displays six doublets
and three singlets in the aromatic region, with one singlet
being twice the intensity of the other two, and triplets
at 3.86 (4H) and 3.93 ppm (4H) corresponding to the R
methylene groups on the alkoxy side chains and a singlet
The bromide 14 (2.15 equiv) was reacted with 1,4-
didecyloxybenzene-2,5-diboronic acid 1619 (1 equiv) to
produce the p-quinquephenyl 18 in 85% isolated yield.
(19) Goldfinger, M. B.; Swager, T. M. J . Am. Chem. Soc. 1994, 116,
7895-6.

Synthesis of Substituted Quinquephenyls
J . Org. Chem., Vol. 63, No. 5, 1998 1679
at 3.89 ppm for the terminal methoxy groups. The 13C
NMR spectrum of 19 displays all four acetylenic reso-
nances but only 16 of the 20 expected aromatic reso-
nances, undoubtedly due to coincidental overlap of some
of the signals. In the 1H NMR of compound 24 the
signals in the aromatic region corresponding to the
pendant p-alkoxyphenyl rings show up at 6.75 and 7.08
ppm as non-first-order multiplets. This may be due to
slow conformational dynamics. The presence of several
low-intensity broad resonances (analytically pure mate-
rial) lends support to the supposition of conformational
dynamics. Also present in the aromatic region are three
singlets corresponding to the hydrogens on the middle
three rings of the quinquephenyl system and an aryl ABD
spin system corresponding to the outermost ring of the
quinquephenyl system. All of these signals of 24 are also
broad. A lone triplet and a corresponding broad reso-
nance are present at 3.92 and 3.81 ppm, respectively
corresponding to the methylenes next to the oxygen on
the pendant alkoxy phenyl rings. 24 also displays three
singlets at 2.28, 2.32, and 2.38 ppm, corresponding to the
three chemically nonequivalent methyl groups. The 13C
NMR spectrum of 24 displays three of the four expected
acetylene resonances and 17 of 23 expected aromatic
resonances. This is again due to coincidental overlap of
some of the signals, perhaps as a result of the slow
conformational dynamics. Interestingly, compound 18
which displays 21 out of 21 expected resonances in the
13C NMR shows an intense band at 296 nm in its UV-
vis absorption spectrum which we ascribe to a relatively
high degree of planarity for the p-phenylene backbone.
Compound 24, which appears to be conformationally
cyclized systems and to provide an additional NMR
diagnostic. Much to our disappointment, cyclization of
the p-quinquephenyl systems 18, 19, and 24 did not
proceed with the same success enjoyed for the p-terphenyl
systems. These cyclizations often produced mixtures of
products whose structures were no longer symmetric,
giving rise to complex NMR spectra. In addition, the
nature of the cyclized product appeared to be highly
dependent on the nature of the appended functionality.
We will begin our discussion with the cyclization of
compound 24, as its products have been the most
thoroughly characterized.
The acid-catalzyed cyclization of 24 gave as the major
isolable product (67% after silica gel chromatography) a
yellow solid. LDI-MS showed that this product had the
same molecular weight as 24. A cursory glance at the
1H NMR clearly indicated that the reaction had led to
extensive desymmetrization, as indicated by the presence
of six nonequivalent methyl signals. Also, there were
eight singlets in the aromatic region along with some
doublets and more complex (overlapped) multiplets. We
were particularly puzzled by the presence of a singlet at
6.82 ppm. On the basis of our experience with com-
pounds of the type 1-5 we expected the bay region
protons to appear as singlets downfield of about 8 ppm.5
There were also two doublets in the vinyl region, one at
6.16 ppm, and a rather broad one at 6.20 ppm. In
addition, there was a singlet (3H) at 1.21 ppm and a
doublet (3H, J ) 1.4 Hz) at 2.64 ppm. The 1H COSY
clearly indicated that the doublet at 2.64 ppm was
coupled to the broad doublet at 6.20 ppm. This appeared
to indicate the presence of an allylic methyl group. 1H
COSY also indicated the presence of an ABD spin system
with a doublet of doublets at 6.90 ppm (J ) 2.6 and 8.5
Hz), and doublets at 6.16 ppm (J ) 2.6 Hz) and 8.01 ppm
(J ) 8.5 Hz). This implied the presence of a trisubsti-
tuted aromatic ring with substitution in the 1, 2, and 4
positions. In the 13C NMR there were four signals
between 155 and 160 ppm, indicating the presence of four
nonequivalent aromatic carbons attached to oxygen,
which again implies desymmetrization. 13C NMR and
DEPT showed the presence of two saturated quaternary
carbons at 46.28 and 61.36 ppm. The presence of these
upfield signals for quaternary carbons along with the
methyl singlet at 1.21 ppm in the 1H NMR clearly
indicate the interruption of aromaticity. Aryl methyl
groups typically appear downfield of 2 ppm. This far
upfield shift is unlikely to be due to severe shielding
effects, as even the methyl group of 9-methyl-1,8-diphe-
nylanthracene was reported by House to appear between
1
dynamic by H NMR, displays only a very weak band at
286 nm, suggesting a less planar structure than 18. Both
18 and 24 display absorption maxima at 342 nm with
shoulders at 364 nm, in agreement with the terphenyl
systems reported earlier which serve as precursors to
compounds 1-5.5
In light of the complications due to the dynamic
behavior observed in the NMR, mass spectrometry was
key in the structure assignments. Fast atom bombard-
ment mass spectrometry (FAB-MS), typically favored
over chemical ionization methods for relatively high
molecular weight species, proved to be an inadequate tool
for the characterization of the p-quinquephenyl model
systems. We did obtain positive results, however, by
employing laser desorption ionization mass spectrometry
(LDI-MS). The measurements were performed without
matrix in positive ion mode. Original measurements
were made using p-quaterphenyl (Aldrich) for molecular
weight calibration. Upon successful confirmation of an
unknown’s molecular weight, that compound then be-
came a member of a pool of molecular weight standards
to be used in subsequent measurements. Measurements
employing standard peptides for calibration afforded
inaccurate results. Extremely clean molecular ion sig-
nals were observed for 18, 19, and 24. LDI-MS also
provided positive results for the measurements of the
boronic acids 15 and 22, which gave molecular weights
corresponding to 3M+ - 3H2O, indicating the likely
formation of cyclotrimers. The mass spectra of the
bromides 14 and 21 could be easily measured by FAB-
MS.
1
1.49 and 1.59 ppm in the H NMR.20 On the basis of the
above information, we suspected that the major product
of the cyclization of 24 was 25 (see Scheme 3). Upon
searching the literature, we discovered that Harvey had
found that the methyl group of a methylated dihydro-
phenanthrene system appeared at 1.34 ppm (see Figure
2).21 The allylic methyl in this same compound appeared
at 2.12 ppm (J ) 1.4 Hz). The singlet at 6.82 ppm in the
1H NMR could now be assigned to the indenyl proton
(6.82 ppm in indene).22 The structure 25 is consistent
with all of our observations.
Cycliza tion of p-Qu in qu ep h en yl System s. The
terminal methoxy groups of 18 and 19 were appended to
simplify the NMR spectra of both the precyclized and
(20) House, H. O.; Hrabie, J . A.; Veer, D. V. J . Org. Chem. 1986,
51, 921.
(21) Harvey, R. G.; Lindlow, D. F. Tetrahedron 1972, 28, 2909.

1680 J . Org. Chem., Vol. 63, No. 5, 1998
Goldfinger et al.
Sch em e 3
Sch em e 4
F igu r e 2. 1H NMR data for a dihydrofluoranthene system.
The spiro linkage of 25 presumably forms after one of
the “central” phenylethynyl moieties is successfully cy-
clized. The vinyl carbocation formed from the other
“central” phenylethynyl moiety then, instead of attacking
the carbon center which would produce a six-membered
ring, attacks the ipso position to create a spiro linkage.
This intermediate is irreversibly trapped as a result of
the ability of the outer phenyl ring to eliminate a proton.
This is not entirely unexpected, since it is well-known
that, in general, ring closure to form five-member rings
is significantly faster than for six-member rings.23,24 This
type of event was not observed in the p-terphenyl systems
due to the absence of a trapping mechanism, or more
specifically the absence of a configuration requiring the
cyclization of two phenylethynyl moieties onto the same
backbone aryl ring. Electrophilic attack at the ipso
position may have indeed been occurring via the vinyl
(22) Pretsch, E.; Seibl, J .; Simon, W.; Clerc, T. In Tables of Spectral
Data for Structure Determination of Organic Compounds, 3 ed.;
Fresenius, W., Huber, J . F. K., Pugnor, E., Rechnitz, G. A., Simon,
W., West, T. S., Eds.; Springer-Verlag: New York, 1989; pp H240.
(23) Carey, F. A.; Sundberg, R. J . In Advanced Organic Chemistry
Part A: Structure and Mechanism, 3 ed.; Plenum Press: New York,
1990; pp 163-167.
cationic intermediate i (Scheme 4) which then forms the
cationic spiro intermediate ii. In the case of the terphe-
nyl systems, there is no trapping mechanism available,
thus permitting ii to undergo a rearrangement leading
(24) March, J . In Advanced Organic Chemistry, 3 ed.; J ohn Wiley
& Sons: New York, 1985; p 212.

Synthesis of Substituted Quinquephenyls
J . Org. Chem., Vol. 63, No. 5, 1998 1681
to the dibenzo[a,h]anthracene product. In the case of the
quinquephenyl system, the corresponding spiro interme-
diate iii is trapped by the pendant alkoxyphenyl moiety,
leading to the spiro product 25.
We were successful in preparing a defect-free cycliza-
tion product in modest chemical yield (48%) by employing
iodonium as the electrophile. The tetraiodide 26 was
prepared as a bright yellow solid by employing iodonium
generated in situ by the reaction of mercury(II) trifluo-
roacetate with I2 in the presence of 2,6-lutidine.5 The
1H NMR spectrum of 26 is straightforward and contains
four doublets corresponding to the protons on the pendant
p-alkoxyphenyl groups and two doublets of lower inten-
sity corresponding to the protons on the terminal rings
of the fused aromatic system. Also present in the
aromatic region are singlets at 9.25 and 9.46 ppm, which
represent the two bay region protons. The LDI-MS of
this compound displays the molecular ion signal at m/z
1659 as well as signals at m/z 1532, 1404, 1277, and 1149,
each corresponding to the loss of an iodide. The combi-
nation of poor solubility and thermal instability precluded
the procurement of a 13C NMR spectrum for 26 and
limited the degree to which the material could be puri-
fied.
Removal of the iodides of 26 by lithium-halogen
exchange followed by a 2-propanol quench provided 27
in 83% isolated yield. The 1H NMR spectrum of 27
displays six aromatic doublets, with two being of lower
intensity, but now contains four singlets corresponding
to the two bay protons (8.81 and 9.06 ppm) and the two
new protons (7.67 and 7.83 ppm) introduced by the
reaction. The greater solubility of 27 allowed for the
aquisition of a 13C NMR spectrum which displays the
expected 27 aromatic resonances and a lack of acetylene
carbons and carbons corresponding to the spiro system
(46 and 61 ppm) discussed above. LDI-MS displays the
molecular ion signal at m/z 1155, and combustion analy-
sis is accurate to within 0.04% for carbon and 0.24% for
hydrogen.
F igu r e 3. Absorption (solid line) and emission (dashed line)
spectra for compounds 25 (top), 26 (middle), and 27 (bottom).
Note that 26 does not display any emission under the
experimental conditions due to a heavy-atom effect.
and 6 positions of the pendant 4-alkoxyphenylethynyl
moiety could prevent spiro linkages as well as alcohol
elimination products. Recall that 18 did not produce any
spiro linkages but did give products resulting from
elimination of decyl alcohol. Also, 18 did not show any
of the conformational dynamics that complicated the
NMR spectrum of 24. Guided by these facts, the target
33 was selected. It was synthesized in a manner
analogous to that used for 18 (see Scheme 5).
The dibromide 28 (prepared in five steps from 2,6-
dimethyl-4-bromophenol and 1,4-diiodo-2,5-dibromoben-
zene) was converted to the mixed iodobromo compound
29 as detailed earlier for the conversion of 11 to 12. The
introduction of the extra methyl groups on the phenyl-
ethynyl moiety made the Suzuki coupling more difficult.
The earlier protocol failed completely in this casesmost
likely due to the greater steric hindrance of the extra
methyl groups. This problem was easily overcome by
employing the Kishi modification wherein TlOH is used
as the base instead of KOH.25 The more readily available
Tl2CO3 was also found to work satisfactorily. The use of
the thallium protocol conferred another benefit, the
reaction could now be run in THF instead of nitroben-
zene, and this greatly simplified the problem of solvent
removal. Suzuki coupling of 29 with 2,5-dimethoxyphe-
The electronic spectra for 25-27 are displayed in
Figure 3. Their absorption spectra display the low
intensity absorptions on the low energy side of λmax as
was observed in systems 1-5.
It is noteworthy to report that the cyclization of the
p-quinquephenyls 18 and 19 did not exhibit the same
behavior as observed for the cyclization of 24; i.e., there
was no evidence of spiro ring junctures. Cyclization of
18 did produce small quantities of a product in which
the loss of decyloxy was detected (by LDI-MS). The
dominant product, isolated in 38% yield, did not undergo
loss of a decyloxy side chain as evidenced by LDI-MS (m/z
1892). The 1H NMR spectrum of the cyclized product
indicates that the molecule has been desymmetrized.
However, the spectrum suggests only a minor perturba-
tion from clean cyclization on the basis of the splitting
patterns present. Such a perturbation is likely due to
1,2-phenyl migration similar to what we have observed
in certain molecular systems.5 We hesitate however,
without X-ray crystallographic evidence, to provide an
unambiguous structure assignment. Interestingly, the
cyclization product of 18 displays an emission at 476 nm
which is closer to 27 (472 nm) than to 25 (438 nm). The
products obtained by the TFA-induced cyclization of 19
again appear to be perturbed only slightly from what is
to be considered a clean cyclization.
Syn th esis a n d Cycliza tion of a Mod ified System .
At this juncture it had become clear that blocking the 2
(25) Uenishi, J .-I.; Beau, J .-M.; Armstrong, R. W.; Kishi, Y. J . Am.
Chem. Soc. 1987, 109, 4756.

1682 J . Org. Chem., Vol. 63, No. 5, 1998
Goldfinger et al.
Sch em e 5
Sch em e 6
nylboronic acid 30 in the presence of Tl2CO3 gave the
bromide 31. The effect of the added bulk of the methyls
again manifested itself when we attempted to couple 31
with 16, which produced no detectable coupling product.
Conversion of 31 to the iodide 32 followed by Suzuki
coupling (using Tl2CO3 in THF as before) with 16 gave
33 in 82% yield. The NMR, UV-vis, and fluorescence
spectra of 33 are similar to those of 18.
the pendant aromatic rings and two singlets for the
blocking methyl groups (at the 2 and 6 positions of the
pendant aromatic ring). However, there are four signals
observed for each in the 1H NMR. This appears to
suggest that the pendant aromatic rings are conforma-
tionally locked with a dihedral angle of between 0° and
90°. The effects of this conformational lock are also
evident in the 13C NMR spectrum. In the absence of
conformational constraints, one would expect to see 27
peaks in the region downfield of 100 ppm (the aromatic
region). If the system were conformationally locked, one
would expect to see a total of 31 peaks in the aromatic
region. The 13C NMR of 34 shows 30 signals in the
aromatic region. Again all 31 signals are not seen
2due to some coincidental overlap. The UV-vis and
fluorescence spectra of 34 are similar to those of 27 (see
Figure 4).
Cyclization of 33 with trifluoroacetic acid in methylene
chloride gave 34 in 80% yield (see Scheme 6). Unfortu-
nately, this compound is of limited stability and decom-
posed slowly on silica or after extended (2 days) storage
1
at room temperature. The H NMR of this compound is
somewhat more complicated than expected. The four
singlets and two doublets expected from the aromatic core
are seen and are fairly clean. In addition, the two
methoxy groups on the aromatic core also show up as
two clean singlets, one of which is moved significantly
upfield whereas the other has moved downfield by a
similar amount relative to their position in 33. It is thus
obvious that the cyclization reaction has not led to any
desymmetrization of the molecule. This is also substan-
tiated by the proton-decoupled 13C NMR spectrum. In
the region between 150 and 160 ppm there are five lines
as expected for the aromatic carbons attached to the
various oxygens in 34. These NMR data are in concor-
dance with those of 27. The signals from the pendant
alkoxy phenyl groups are more complex, most likely due
to hindered rotation. If there were free rotation one
Recall that iodonium cyclization of 24 led to 26. The
application of the same protocol to 33 gave the tetraiodide
35 in 90% yield. As was observed for 26, 35 also has
very limited stability. In fact, 35 was found to be even
less stable than 26, again making it impossible to obtain
a
13C NMR spectrum for a tetraiodinated product. The
1H NMR spectrum of 35 was very similar to that of 34
and is in general concordance with that of 26. It shows
the expected two singlets and two doublets for the
aromatic core. The two methoxy groups also exhibited
analogous, but more pronounced, shifts. The pendant
p-alkoxyphenyl groups showed four singlets in the aro-
1
would expect to see, in the H NMR, just two singlets for

Synthesis of Substituted Quinquephenyls
J . Org. Chem., Vol. 63, No. 5, 1998 1683
Synthetic manipulations were performed under an argon
atmosphere using standard Schlenk techniques.
1,4-Did ecyloxyben zen e-2,5-d ibor on ic Acid (16). 1,4-
Didecyloxy-2,5-diiodobenzene (15 g, 0.0233 mol) was dissolved
in 200 mL of THF and the solution was cooled to -70 °C. tert-
BuLi (61.2 mL, 1.64 M) was added and the temperature was
allowed to rise to -55 °C over 3 h. The temperature was then
brought to -20 °C and allowed to remain there for 45 min.
The solution was recooled to -60 °C and B(OMe)3 (15.91 mL,
0.140 mol) was quickly added via syringe in one portion. The
solution was stirred at room-temperature overnight and 100
mL of 10% HCl was added. After 90 min the solution was
filtered and the solid collected and heated in boiling water.
After filtering, the solid was again collected and heated in
boiling hexanes to remove monoboronic acid. The insoluble
solid was collected and dried in vacuo to afford 9.50 g (85%) of
the colorless solid. 1H NMR (500 MHz, DMSO-d6): δ 0.84 (t,
6H, J ) 7.12 Hz), 1.2-1.5 (H28), 1.71 (quint, 4H, J ) 7.50
Hz), 3.98 (t, 4H, J ) 6.50 Hz), 7.18 (s, 2H), 7.75 (s, 4H). Anal.
Calcd for C26H48O6B2: C, 65.29; H, 10.12. Found: C, 65.29;
H, 10.13.
F igu r e 4. Absorption (solid line) and emission (dashed line)
spectra for compound 34.
matic region and four singlets for the blocking methyl
groups, again most likely due to conformational con-
straints.
5,12-Bis(4-d od ecyloxyp h en yl)-1,4,8,11-t et r a m et h oxy-
6,13-bis(4-m eth oxyp h en yl)d iben zo[a ,h ]a n th r a cen e (10).
To a 25 mL Schlenk flask charged with 2 (0.072 g, 0.062 mmol),
p-methoxyphenylboronic acid (0.093 g, 0.61 mmol), Pd(dba)2
(0.0007 g, 0.001 mmol), triphenylphosphine (0.005 g, 0.019
mmol), and KOH (0.150 g, 2.67 mmol) were added 1.5 mL of
H2O and 4 mL of nitrobenzene. The mixture was heated to
95 °C and allowed to stir for 14 h. After cooling to room
temperature the mixture was diluted with ethyl ether (100
mL) and washed with 5% NaOH (3 × 30 mL), H2O (30 mL),
5% HCl (2 × 40 mL), and H2O (30 mL). After drying (MgSO4)
the ethyl ether was removed using standard rotary evapora-
tion. The remaining nitrobenzene was removed under high
vacuum (0.01 Torr) while being heated (95 °C). The crude
product was purified by silica gel chromatography (2:2:1
hexanes-ethyl acetate-CHCl3) to provide 10 (mp 168-170 °C)
as a bright yellow solid (0.066 g, 94.9%). 1H NMR (500 MHz,
CDCl3): δ 0.87 (t, 6H, J ) 6.77 Hz), 1.26-1.44 (m, 36H), 1.73
(quint, 4H), 3.24 (s, 6H), 3.59 (s, 6H), 3.82 (s, 6H), 3.88 (t, 4H,
J ) 6.68 Hz), 6.63 (d, 4H, J ) 8.65 Hz), 6.84 (d, 4H, J ) 8.64
Hz), 6.89 (d, 4H, J ) 8.64 Hz), 6.92 (d, 2H, J ) 8.84 Hz), 6.98
(d, 2H, J ) 8.83 Hz), 7.07 (d, 4H, J ) 8.63 Hz), 9.89 (s, 2H);
13C NMR (62.9 MHz, CDCl3): δ 14.11, 22.68, 26.06, 29.36,
29.62, 31.91, 55.15, 55.35, 57.32, 67.92, 109.12, 111.64, 112.52,
112.84, 114.08, 122.05, 125.34, 127.46, 130.18, 131.60, 132.35,
133.43, 134.34, 137.19, 140.01, 151.75, 153.23, 156.08, 157.57.
UV-vis (CHCl3) λmax (ꢀ, cm-1 M-1): 430 (13 600), 406 (11 300),
376 (19 200), 358 (24 600), 324 (61 100), 282 (43 000) nm.
Luminescence spectrum (CHCl3) λmax (rel int): 436 (1), 460
(0.58) nm. HRMS (FAB): found m/z 1130.6678 (M+), calcd for
Con clu sion
We have extended our earlier organometallic coupling
strategy to the synthesis of p-quinquephenyl systems. We
have demonstrated the versatility of and further ex-
tended our electrophile-induced cyclization to produce
larger planar conjugated systems which have potential
applications in many fields. In this work we have shown
that this versatile two-step protocol can be used to
produce aromatic systems containing nine annelated
rings. The reaction conditions are very mild, thus
allowing the production of these characteristically rela-
tively sensitive compounds in synthetically useful
amounts. Use of iodonium as the electrophile leads to
functionalized polycyclic aromatic systems which can
undergo further C-C bond forming reactions to yield
more complex systems. A side reaction that produces an
interesting indenyl spiro ring system has also been
described. The use of blocking groups at the 2 and 6
positions of the pendant alkoxyphenylethynyl groups
prevents the formation of the indenyl spiro ring system.
Exp er im en ta l Section
Gen er a l Meth od s. NMR spectra (1H and 13C) were ob-
tained on Bruker AC-100, AC-200, AC-250, and AMX-500
spectrometers using CDCl3 as solvent. Chemical shifts are
reported in ppm relative to residual protio chloroform (7.24
C
76H90O8 m/z 1130.6635.
1-Br om o-2,5-b is(4-d od ecyloxyp h en ylet h yn yl)-4-iod o-
ben zen e (12). To a 500 mL Schlenk flask containing 1,4-
dibromo-2,5-bis-(4-dodecyloxyphenylethynyl)benzene 115 (4.7
g, 5.84 mmol) was added 400 mL of THF. The mixture was
cooled to -78 °C and n-BuLi (3.95 mL, 1.7 M, 6.72 mmol) was
added. The cooling bath was removed until the solution
became homogeneous (ca. 10 min), at which time the solution
was allowed to stir for an additional 5 min. After recooling to
-78 °C, solid I2 (3 g, 11.8 mmol) was added. Again, the cooling
bath was removed and the mixture allowed to stir until
homogeneous. After stirring for 5 min the reaction was
quenched by the addition of 5% NaOH. The mixture was
diluted with 250 mL of ethyl ether (40 mL of CHCl3 was added
for solubility), washed with additional 5% NaOH and H2O, and
dried (MgSO4). Removal of the solvent under reduced pressure
followed by recrystallization from CHCl3 (2×) provided com-
pound 12 (mp 114-115 °C) as a colorless solid (3.99 g, 80.2%).
1H NMR (250 MHz, CDCl3): δ 0.86 (t, 6H, J ) 7.0 Hz), 1.2-
1.5 (36H), 1.77 (m, 4H), 3.95 (t, 4H, J ) 6.53 Hz), 6.86 (br d,
4H, J ) 7.7 Hz), 7.47 (d, 2H, 8.47 Hz), 7.49 (d, 2H, 8.46 Hz),
7.67 (s, 1H), 7.96 (s, 1H); 13C NMR (62.9 MHz, CDCl3): δ 14.10,
22.68, 25.98, 29.13, 29.34, 29.58, 31.89, 68.11, 85.53, 89.38,
96.10, 96.88, 98.14, 114.13, 114.62, 124.58, 126.37, 130.67,
ppm, H; 77.0 ppm, 13C). Microanalyses and high-resolution
1
mass spectra (HRMS) were obtained at the University of
Pennsylvania instrumentation center. Silica gel chromatog-
raphy was performed on 40 µm silica gel (Baker). Infrared
spectra were recorded on a Perkin-Elmer 1760-X spectrometer.
Samples were prepared by evaporation of solutions of dissolved
compounds directly onto KBr plates. UV-vis spectra were
recorded in CHCl3 on a Hewlett-Packard 8452A diode array
spectrophotometer. Luminescence spectra were recorded in
CHCl3 using a Photon Technology International A1010 lumi-
nescence spectrometer. Emission measurements were per-
formed in a four-sided quartz cell at room temperature and
are uncorrected for detector response. Emission measure-
ments of precyclized and cyclized materials were made at
excitation wavelengths of 330 and 365 nm, respectively.
All solvents were distilled by vacuum transfer. THF was
stored over CaH2 before being distilled from sodium benzophe-
none ketyl. Toluene was distilled from sodium metal. Ni-
trobenzene and methylene chloride were distilled from P2O5.
Nitrobenzene was stored in the dark. Diisopropylamine
(DIPA) was distilled from solid KOH pellets.

1684 J . Org. Chem., Vol. 63, No. 5, 1998
Goldfinger et al.
133.23, 133.58, 134.76, 141.83, 159.85. HRMS (FAB): found
m/z 850.2800 (M+), calcd for C46H60O2BrI m/z 850.2821. HRMS
(FAB): found m/z 627.0380 (M+ + H), calcd for C30H29O2BrI
(12-C4) m/z 627.0395. Anal. Calcd for C46H60BrIO2: C, 64.86;
H, 7.10. Found: C, 65.00; H, 7.08.
88.41, 93.52, 93.89, 113.35, 114.38, 114.49, 115.23, 115.44,
116.29, 120.79, 123.40, 125.51, 129.49, 130.55, 132.38, 132.49,
132.82, 132.89, 134.69, 139.34, 141.49, 150.22, 159.05, 159.21.
UV-vis (CHCl3) λmax (ꢀ, cm-1 M-1): 364 (92 200), 342 (119 000),
296 (82 100) nm. Luminescence spectrum (CHCl3) λmax (rel
int): 422 nm. LDI-MS: m/z 1892 (100, M+), 1784 (15), 1751
(15, M+ - C10H21), 1613 (10). Anal. Calcd for C132H178O8: C,
83.76; H, 9.48. Found: C, 83.85; H, 9.66.
4-Br om o-2,5-bis(4-d od ecyloxyp h en yleth yn yl)-4′-m eth -
oxy-1,1′-bip h en yl (14). A Schlenk flask was charged with
12 (3.65 g, 4.29 mmol), p-methoxyphenylboronic acid (0.716
g, 4.71 mmol), Pd(dba)2 (0.025 g, 0.043 mmol), triphenylphos-
phine (0.168 g, 0.645 mmol), and KOH (2.60 g, 46.3 mmol).
H2O (15 mL) and nitrobenzene (25 mL) were added, and the
mixture was heated at 90 °C for 12 h. After cooling to room
temperature, the mixture was diluted with 200 mL of ethyl
ether and washed with 5% NaOH (2 × 50 mL) and H2O (40
mL). After removal of the ethyl ether by rotary evaporation,
the compound was precipitated by the addition of methanol
to the remaining nitrobenzene. Filtration, followed by puri-
fication by silica gel chromatography (3:2 CHCl3-hexanes),
afforded 14 (mp 80-81 °C) as a colorless solid (3.18 g, 89.3%).
1H NMR (250 MHz, CDCl3): δ 0.86 (t, 6H, J ) 7.0 Hz), 1.2-
1.5 (36H), 1.77 (m, 4H), 3.86 (s, 3H), 3.92 (t, 2H, J ) 6.67 Hz),
3.95 (t, 2H, J ) 6.61 Hz), 6.81 (d, 2H, J ) 8.72 Hz), 6.87 (d,
2H, J ) 8.76 Hz), 6.98 (d, 2H, J ) 8.70 Hz), 7.27 (d, 2H, J )
8.66 Hz), 7.50 (d, 2H, J ) 8.70), 7.53 (s, 1H), 7.60 (d, 2H, J )
8.65 Hz), 7.81 (s, 1H); 13C NMR (62.9 MHz, CDCl3): δ 14.10,
22.67, 25.97, 29.13, 29.35, 29.58, 31.89, 55.24, 68.01, 86.90,
94.85, 95.59, 113.33, 114.48, 122.60, 122.83, 125.16, 130.31,
131.37, 132.87, 133.17, 135.75, 141.83, 159.40, 159.60. HRMS
(FAB): found m/z 831.4370 (M+ + H), calcd for C53H68BrO3
m/z 831.4351. Anal. Calcd for C53H67BrO3: C, 76.51; H, 8.12.
Found: C, 76.17; H, 8.03.
2,5-Bis(4-d od ecyloxyp h en ylet h yn yl)-4′-m et h oxy-1,1′-
bip h en yl-4-bor on ic Acid (15). Compound 14 (2.0 g, 2.41
mmol) was dissolved in 200 mL of THF and the solution cooled
to -78 °C. After addition of n-BuLi (1.98 mL, 1.7M, 3.37
mmol), the solution was allowed to stir for 15 min before
triisopropyl borate (1.55 mL, 6.72 mmol) was rapidly added
via syringe. The mixture was allowed to warm to room
temperature over 45 min and 5% HCl (50 mL) was added. After
stirring for 1 h, the mixture was diluted with 150 mL of ethyl
ether. The solvent was washed with H2O (3 × 75 mL), dried
(MgSO4), and removed under reduced pressure. Recrystalli-
zation of the crude product from hexane-ethyl acetate (1×)
and CHCl3 (1×) provided 15 as a colorless solid (1.52 g, 79.3%).
1H NMR (250 MHz, CDCl3): δ 0.86 (t, 6H, J ) 7.0 Hz), 1.2-
1.5 (36H), 1.77 (m, 4H), 3.86 (s, 3H), 3.92 (t, 2H, J ) 6.68 Hz),
3.96 (t, 2H, J ) 6.64 Hz), 5.93 (br s, 2H), 6.80 (d, 2H, J ) 8.85
Hz), 6.88 (d, 2H, J ) 8.84 Hz), 6.99 (d, 2H, J ) 8.84 Hz), 7.28
(d, 2H, J ) 8.79 Hz), 7.45 (d, 2H, J ) 8.85 Hz), 7.58 (s, 1H),
7.66 (d, 2H, J ) 8.83 Hz), 8.21 (s, 1H). LDI-MS: m/z 2338
(10, 3M+ - 3H2O), 1577 (10, 2M+ - H2O), 825 (70), 798 (100),
754 (100), 647 (90).
2′′,5′′-Bis(d ecyloxy)-2′,5′,2′′′,5′′′-tetr a k is(4-d od ecyloxy-
p h en ylet h yn yl)-4,4′′′′-d im et h oxy[1,1′:4′,1′′:4′′,1′′′:4′′′,1′′′′]-
qu in qu ep h en yl (18). A Schlenk flask was charged with the
bromide 14 (0.230 g, 0.277 mmol), 16 (0.061 g, 0.128 mmol),
Pd(dba)2 (0.0016 g, 0.0028 mmol), triphenylphosphine (0.011
g, 0.042 mmol), and KOH (0.35 g, 6.24 mmol). After adding 2
mL of H2O and 5 mL of nitrobenzene, the solution was heated
to 85 °C and allowed to stir for 12 h. After cooling to room
temperature, the mixture was diluted with 20 mL of ethyl
ether and washed with 5% NaOH (2 × 10 mL) and H2O (10
mL). After removal of the ethyl ether by rotary evaporation,
the compound was precipitated by the addition of methanol
to remove the remaining nitrobenzene. Filtration, followed
by purification by silica gel chromatography (3:2 CHCl3-
hexanes) provided compound 18 (mp 137-138 °C) as a
colorless solid (0.204 g, 84.6%). 1H NMR (250 MHz, CDCl3):
δ 0.86 (t, 18H, J ) 7.0 Hz), 1.2-1.5 (100H), 1.5-1.8 (m, 12H),
3.80 (t, 4H, J ) 6.60 Hz), 3.88 (s, 6H), 3.92 (t, 8H, J ) 6.50
Hz), 6.65 (d, 4H, J ) 8.79 Hz), 6.79 (d, 4H, J ) 8.82), 7.01 (d,
4H, J ) 8.73 Hz), 7.12 (d, 4H, J ) 8.67), 7.12 (s, 2H), 7.28 (d,
4H, J ) 8.80 Hz), 7.64 (s, 2H), 7.72 (d, 4H, J ) 8.71 Hz), 7.73
(s, 4H); 13C NMR (62.9 MHz, CDCl3): δ 14.10, 22.68, 26.02,
29.10, 29.37, 29.61, 30.32, 31.91, 55.35, 67.97, 69.62, 88.31,
2′,5′,2′′′,5′′′-Tetr a k is(4-d od ecyloxyp h en yleth yn yl)-4,4′′′′-
d im eth oxy[1,1′:4′,1′′:4′′,1′′′:4′′′, 1′′′′]qu in qu ep h en yl (19). Α
Schlenk flask was charged with boronic acid 15 (1.66 g, 2.09
mmol), 1,4-diiodobenzene (0.328 g, 1.00 mmol), Pd(dba)2 (0.011
g, 1.91 × 10-2 mmol), triphenylphosphine (0.078 g, 0.297
mmol), and KOH (1.17 g, 20.9 mmol). Following the addition
of 7 mL of H2O and 20 mL of nitrobenzene, the entire solution
was heated to 85 °C. After stirring overnight the solution was
allowed to cool to room temperature, at which time it was
diluted with 100 mL of CHCl3. After washing with 5% NaOH
(2 × 40 mL), H2O, 5% HCl (2 × 40 mL), and H2O, the solvent
was dried and removed in vacuo. The crude product was
crystallized once from CHCl3-i-PrOH followed by one crystal-
lization from CHCl3. The p-quinquephenyl 19 (mp 157-159
°C) was isolated as a colorless solid (1.38 g, 87.1%). 1H NMR
(250 MHz, CDCl3): δ 0.86 (t, 12H, J ) 7.0 Hz), 1.2-1.5 (72H),
1.77 (m, 8H), 3.85 (t, 4H, J ) 6.60), 3.89 (s, 6H), 3.93 (t, 4H,
J ) 6.50 Hz), 6.73 (d, 4H, J ) 8.82 Hz), 6.81 (d, 4H, J ) 8.84
Hz), 7.02 (d, 4H, J ) 8.80), 7.26 (d, 4H, J ) 8.87 Hz), 7.31 (d,
4H, J ) 8.79 Hz), 7.68 (s, 2H), 7.71 (d, 4H, J ) 8.78 Hz), 7.75
(s, 2H), 7.86 (s, 4H); 13C NMR (62.9 MHz, CDCl3): δ 14.10,
22.67, 25.98, 29.16, 29.34, 29.58, 31.89, 55.33, 68.05, 88.03,
88.14, 93.88, 94.21, 113.37, 114.49, 114.99, 115.17, 121.51,
121.70, 128.87, 130.49, 132.11, 132.87, 133.46, 133.68, 138.96,
141.28, 141.65, 159.26. LRMS (FAB): m/z 1578.7 (15, M+),
1412 (5, M+ - PhOCH3), 752 (100). LDI-MS: m/z 1579 (95,
M+), 1472 (15, M+ - PhOCH3), 1410 (10, M+ - C12H25), 827
(15), 751 (100), 645 (50).
4-Br om o-2,5-bis(4-bu toxyph en yleth yn yl)-2′,5′-dim eth yl-
1,1′-bip h en yl (21). The bromide 21 was prepared as de-
scribed for 14 by substituting 20 for 13 and using the butoxy
side chain derivative (12-C4) of 12. A small excess of boronic
acid was employed (1.03 equiv) and the reaction temperature
was kept at 70 °C. Following purification by silica gel
chromatography (1:1 hexanes-toluene) 21 (mp 142-144 °C)
was isolated as a colorless solid (81%). 1H NMR (200 MHz,
CDCl3): δ 0.94 (t, 3H, J ) 7.71 Hz), 0.96 (t, 3H, J ) 7.66 Hz),
1.46 (m, 4H), 1.70 (m, 4H), 2.16 (s, 3H), 2.33 (s, 3H), 3.91 (t,
2H, J ) 6.42 Hz), 3.96 (t, 2H, J ) 6.43 Hz), 6.74 (d, 2H, J )
8.73 Hz), 6.85 (d, 2H, J ) 8.73 Hz), 7.04 (d, 2H, J ) 8.68 Hz),
7.10-7.14 (m, 3H), 7.41 (s, 1H), 7.47 (d, 2H, J ) 8.70 Hz),
7.78 (s, 1H). HRMS (FAB): found m/z 604.1957 (M+), calcd
for C38H37O2Br m/z 604.1976.
2,5-Bis(4-bu toxyp h en yleth yn yl)-2′,5′-d im eth yl-1,1′-bi-
p h en yl-4-bor on ic Acid (22). Compound 22 was prepared
as described for 15, employing compound 21 as the starting
material. Purification by silica gel chromatography (3:1 hex-
anes-ethyl acetate) provided 22 as a white solid (76%). 1H
NMR (200 MHz, CDCl3): δ 0.95 (t, 3H, J ) 7.79 Hz), 0.97 (t,
3H, J ) 7.74 Hz), 1.47 (m, 4H), 1.75 (m, 4H), 2.19 (s, 3H),
2.35 (s, 3H), 3.92 (t, 2H, J ) 6.44 Hz), 3.97 (t, 2H, J ) 6.41
Hz), 5.97 (s, 2H), 6.76 (d, 2H, J ) 8.68 Hz), 6.88 (d, 2H, J )
8.36 Hz), 7.05-7.16 (m, 5H), 7.43 (s, 1H), 7.45 (d, 2H, J )
8.70 Hz), 8.20 (s, 1H). LDI-MS: m/z 1658 (10, 3M+ - 3H2O),
1119 (20), 593 (90), 564 (100), 520 (30). Anal. Calcd for C38H39
BO4: C, 80.00; H, 6.89. Found: C, 79.48; H, 6.97.
-
2′,5′,2′′′,5′′′-Tet r a k is(4-b u t oxyp h en ylet h yn yl)-2,5,2′′,-
5′′,2′′′′,5′′′′-h exam eth yl[1,1′:4′,1′′: 4′′,1′′′:4′′′, 1′′′′]qu in qu eph e-
n yl (24). To a 200 mL Schlenk flask charged with 22 (1.70 g,
2.98 mmol), 2,5-diiodo-p-xylene (0.485 g, 1.35 mmol), Pd(dba)2
(0.023 g, 0.04 mmol), triphenylphosphine (0.160 g, 0.60 mmol),
and KOH (1.67 g, 29.8 mmol) was added 15 mL of H2O and
45 mL of nitrobenzene. The mixture was allowed to stir for
14 h at 90 °C. After cooling to room temperature the mixture
was diluted with 150 mL of ethyl ether and 30 mL of H2O.
The organic layer was washed with additional H2O, 5% HCl,
and saturated NaCl solution. Following removal of ethyl ether

Synthesis of Substituted Quinquephenyls
J . Org. Chem., Vol. 63, No. 5, 1998 1685
in vacuo, the compound was precipitated by the addition of
methanol to the remaining nitrobenzene. After cooling in a
refrigerator for 2 h, the product was filtered. Recrystallization
from THF-MeOH provided 24 (mp 251-252 °C) as a colorless
solid (1.28 g, 82.1%). 1H NMR (500 MHz, CDCl3): δ 0.91 (t,
6H, J ) 7.43 Hz), 0.95 (t, 6H, J ) 7.43 Hz), 1.37-1.50 (m,
8H), 1.64-1.76 (m, 8H), 2.28 (s, 6H), 2.32 (s, 6H), 2.38 (s, 6H),
3.92 (t, 8H, J ) 6.57 Hz), 6.75 (d, 8H, J ) 8.88 Hz), 7.08 (d,
8H, J ) 8.87 Hz), 7.13 (dd, 2H, J ) 7.78, 1.63 Hz), 7.17 (br s,
2H), 7.20 (d, 2H, J ) 7.79 Hz), 7.29 (s, 2H), 7.52 (s, 2H), 7.57
(s, 2H); 13C NMR (125 MHz, CDCl3): δ 13.79, 19.18, 19.53,
19.62, 20.99, 31.21, 67.62, 67.74, 87.82, 93.87, 94.26, 114.46,
115.22, 122.60, 122.83, 128.33, 129.62, 130.65, 131.2127,
132.33, 132.49, 132.86, 133.39, 134.61, 139.45, 139.90, 143.15,
159.21. UV-vis (CHCl3) λmax (ꢀ, cm-1 M-1): 364 (114 000), 342
(127 000) 286 (45900) nm. Luminescence spectrum (CHCl3)
taken to ensure that the product was kept at temperatures
below 35 °C during all stages of workup/purification. Thermal
instability combined with poor solubility limited the extent to
which this product could be purified/characterized. 1H NMR
(500 MHz, CDCl3): δ 0.99 (t, 6H, J ) 7.42 Hz), 1.02 (t, 6H, J
) 7.36 Hz), 1.48-1.60 (m, 8H), 1.77-1.87 (m, 8H), 1.83 (s, 6H),
2.51 (s, 6H), 3.23 (s, 6H), 4.02 (t, 4H, J ) 6.50 Hz), 4.07 (t,
4H, J ) 6.54 Hz), 6.98 (d, 4H, J ) 8.70 Hz), 7.07 (d, 4H, J )
8.65 Hz), 7.15 (d, 4H, J ) 8.59 Hz), 7.20 (d, 2H, J ) 7.50 Hz),
7.42 (d, 4H, J ) 8.62 Hz), 7.43 (d, 2H, J ) 7.50 Hz), 9.25 (s,
2H), 9.47 (s, 2H). UV-vis (CHCl3) λmax (ꢀ, cm-1 M-1): 440
(73 300), 418 (71 600), 378 (152 000), 328 (88 400), 312 (89 200)
nm. Luminescence spectrum (CHCl3) λmax (rel int): no detect-
able signal. LDI-MS: m/z 1659 (23, M+), 1602 (17, M+
-
C4H9), 1532 (67, M+ - I), 1474 (33, M+ - C4H9 - I), 1404 (100,
M+ - 2I), 1347 (44, M+ - C4H9 -2I), 1277 (79, M+ - 3I), 1220
(41, M+ - C4H9-3I), 1149 (49, M+ - 4I), 1093 (26, M+ - C4H9
- 4I). Anal. Calcd for C84H78O4I4: C, 60.81; H, 4.74. Found:
C, 60.15; H, 4.64.
λmax (rel int): 374 (1), 394 (0.86) nm. LDI-MS: found m/z 1155
(M+). Anal. Calcd for C84H82O4: C, 87.31; H, 7.15. Found: C,
87.32; H, 7.25.
8-Bu toxy-4,6a-dim eth yl-[(5,8-dim eth yl-9-(4-bu toxy-ph e-
n yl))p h en a n th r o[2,3-c]]sp ir o[[(2′-(4-bu toxyp h en yl))(4-(4-
bu toxyp h en yl)-5,8-d im eth yln a p h th o[1,2-f ′])]in d en yl-1′,6-
[6,6a -d ih yd r oflu or a n t h en e]] (25). Compound 25 was
prepared following the general TFA cyclization conditions
described previously.5 Following purification by silica gel
chromatography (50:1 hexanes-THF) compound 25 (mp 144-
145 °C) was isolated as a yellow solid (67%). 1H NMR (500
MHz, CDCl3): δ 0.81 (t, 6H, J ) 7.28 Hz), 0.99 (t, 6H, J )
7.42 Hz), 1.21 (s, 3H), 1.20-1.35 (m, 6H), 1.50-1.60 (m, 12H),
1.78-1.88 (m, 6H), 1.99 (s, 3H), 2.05 (s, 3H), 2.64 (app d, 3H,
J ) 1.40 Hz), 3.12 (s, 3H), 3.21 (s, 3H), 3.63 (t, 2H, J ) 6.50
Hz), 3.75 (m, 2H), 4.02 (t, 2H, J ) 6.50 Hz), 4.03 (t, 2H, J )
6.50 Hz), 6.16 (q, 1H, J ) 1.42 Hz), 6.18 (d, 1H, J ) 2.58 Hz),
6.34 (d, 2H, J ) 8.77 Hz), 6.65 (d, 2H, 8.63 Hz), 6.80 (s, 1H),
6.86 (dd, 1H, J ) 8.48, 2.56 Hz), 6.94 (d, 2H, J ) 8.92 Hz),
6.96 (d, 2H, J ) 8.90 Hz), 7.20 (d, 1H, J ) 7.54 Hz), 7.23 (d,
1H, J ) 7.37 Hz), 7.28-7.34 (m, 4H), 7.39 (br d, J ) 7.32 Hz),
7.54 (s, 1H), 7.66 (s, 1H), 7.98 (d, 1H, J ) 8.46 Hz), 8.01 (s,
1H), 8.03 (s, 1H), 8.57 (s, 1H), 8.62 (s, 1H), 9.17 (s, 1H); 13C
NMR (125 MHz, CDCl3, DEPT): δ 13.74 (CH3), 13.90 (CH3),
17.69 (CH3), 18.99 (CH3), 19.09 (CH2), 19.14 (CH2), 19.31 (CH2),
24.97 (CH3), 25.18 (CH3), 26.83 (CH3), 27.06 (CH3), 29.70 (CH2),
31.15 (CH2), 31.21 (CH2), 31.44 (CH2), 46.28, 61.36, 67.25
(CH2), 67.50 (CH2), 67.81 (CH2, 2C), 112.22 (CH), 112.83 (CH),
113.64 (CH), 114.07 (CH), 118.87 (CH), 121.15 (CH), 124.79
(CH), 126.21 (CH), 126.41, 126.47 (CH), 127.03, 128.50 (CH),
128.73, 129.54 (CH), 129.83 (CH), 129.92 (CH), 130.01 (CH),
130.13 (CH), 130.24 (CH), 130.28 (CH), 130.32 (CH), 130.47
(CH), 130.53 (CH), 130.61, 130.90 (CH), 131.10, 131.59, 132.09,
132.27, 132.37, 132.59, 132.66, 132.90, 133.22, 133.79, 134.01,
134.93 (CH), 137.68, 137.72, 138.25, 138.55, 139.41, 140.61,
144.44, 145.99, 147.71, 157.76, 158.16, 158.20, 159.50. UV-
vis (CHCl3) λmax (ꢀ, cm-1 M-1): 418 (18 800), 398 (26 500), 370
(43 500), 338 (109 000), 290 (75 200) nm. Luminescence
spectrum (CHCl3) λmax (rel int): 438 (1), 462 (0.73) nm. LDI-
MS: m/z 1155 (M+).
5,9,16,20-Tetr akis(4-bu toxyph en yl)-6,10,17,21-tetr aiodo-
1,4,8,12,15,19-h e xa m e t h ylb is(p h e n a n t h r o[2,3-a ,h ]a n -
th r a cen e) (26). A solution of 24 (0.140 g, 0.121 mmol) in 100
mL of 1,2-dichloroethane was subjected to two freeze-pump-
thaw cycles. After warming to room temperature the solution
was heated until homogeneous and then allowed to cool to
room temperature, remaining homogeneous. To a separate
flask charged with I2 (0.427 g, 1.68 mmol) was added 18.62
mL of a Hg(TFA)2-CH2Cl2 solution (0.03 M, 0.559 mmol)
followed by 2,6-lutidine (65 µL, 0.558 mmol). After cooling of
both solutions to 0 °C, the solution of 24 was cannulated into
the iodonium solution over 2 min. After stirring for 15 min,
the reaction was quenched with 50 mL of 5% NaOH. Ad-
ditional washing of the organic layer with 5% NaOH, H2O,
5% HCl, and H2O followed by drying (MgSO4) and removal of
solvent in vacuo provided the crude product which was
crystallized from dilute CHCl3-ethanol (0.96 g, 47.7%).
Note: It was previously determined that the tetraiodide
product 26 is thermally sensitive, therefore strict care was
5,9,16,20-Tetr a k is(4-bu toxyp h en yl)-1,4,8,12,15,19-h ex-
a m eth ylbisp h en a n th r o[2,3-a ,h ]a n th r a cen e (27). To a 500
mL Schlenk flask containing 26 (0.066 g, 0.040 mmol) was
added 250 mL of THF. The heterogeneous mixture was cooled
to -78 °C and t-BuLi (2 mL, 1.46 M, 2.92 mmol) was added.
The cooling bath was removed until the solution became
homogeneous (ca. 10 min), at which time the solution was
allowed to stir for an additional 2 min. After recooling to -78
°C, 5 mL of i-PrOH was rapidly added. After allowing to warm
to room temperature the mixture was diluted with 150 mL of
ethyl ether, washed with 5% HCl (2 × 60 mL) and H2O, and
dried (MgSO4), and the solvent was removed by rotary
evaporation. Purification of the crude product by silica gel
chromatography (3:2 toluene-hexanes) provided 27 (mp >280
×a1C) as a bright yellow solid (0.038 g, 82.7%). 1H NMR (500
MHz, CDCl3): δ 1.03 (t, 6H, J ) 7.40 Hz), 1.04 (t, 6H, J )
7.37 Hz), 1.51-1.60 (m, 8H), 1.81-1.90 (m, 8H), 2.05 (s, 6H),
2.75 (s, 6H), 3.22 (s, 6H), 4.06 (t, 4H, J ) 6.54 Hz), 4.11 (t,
4H, J ) 6.54 Hz), 6.98 (d, 4H, J ) 8.66 Hz), 7.11 (d, 4H, J )
8.63 Hz), 7.26 (d, 2H, J ) 7.50 Hz), 7.34 (d, 4H, J ) 8.61 Hz),
7.43 (d, 2H, J ) 7.49 Hz), 7.65 (d, 4H, J ) 8.63 Hz), 7.67 (s,
2H), 7.83 (s, 2H), 8.81 (s, 2H), 9.06 (s, 2H); 13C NMR (125 MHz,
CDCl3): δ 13.90, 19.33, 19.36, 25.21, 26.72, 30.16, 31.45, 31.52,
67.84, 67.91, 114.10, 114.75, 127.45, 128.12, 129.31, 129.42,
129.50, 129.89, 130.10, 130.15, 130.20, 130.35, 130.69, 131.98,
132.03, 132.18, 132.35, 133.30, 133.34, 133.92, 134.10, 137.74,
137.86, 138.58, 138.62, 158.08, 158.26. UV-vis (CHCl3) λmax
(ꢀ, cm-1 M-1): 464 (3920), 434 (63 500), 410 (58 500), 364
(106 000), 324 (76 800), 294 (55 800). Luminescence spectrum
(CHCl3) λmax (rel int): 472 (1), 444 (0.46) nm. LDI-MS: m/z
1188 (10), 1172 (10), 1155 (100, M+), 1145 (15), 618 (10). Anal.
Calcd for C84H82O4: C, 87.31; H, 7.15. Found: C, 87.27; H,
7.39.
2,5-Bis(4-octyloxy-2,6-d im eth ylp h en yleth yn yl)-1,4-d i-
br om oben zen e (28) was btained as a pale yellow solid (mp
150-152 °C) in 72% yield using the method described for 11.5
1H NMR (CDCl3, 200 MHz): δ 7.74 (s, 2H, CHdC(Br)), 6.63
(s, 4H, OCdCH), 3.95 (t, 4H, J ) 6.5 Hz, OCH2), 2.52 (s, 12H,
CdC(CH3)), 1.81-1.71 (m, 4H, OCH2CH2), 1.30 (br s, 20H,
CH2), and 0.89 (t, 6H, J ) 7 Hz, CH2CH3). 13C NMR (CDCl3,
125 MHz): δ 159.42, 142.78, 135.67, 126.64, 122.88, 114.31,
113.18, 95.04, 93.80, 67.94, 31.82, 29.34, 29.24, 26.03, 22.66,
21.56, and 14.08. HREIMS: calcd for C42H52Br2O2 746.2334,
observed 746.2335.
2,5-Bis(4-octyloxy-2,6-d im eth ylp h en yleth yn yl)-1-iod o-
4-br om oben zen e (29) was obtained as a pale yellow solid (mp
102-103 °C) in 80% yield by utilizing the same procedure as
was used for 12. 1H NMR (CDCl3, 200 MHz): δ 7.97 (s, 1H,
CHdC(I)), 7.70 (s, 1H, CHdC(Br)), 6.63 (s, 4H, OCdCH), 3.96
(t, 4H, J ) 6.5 Hz, OCH2), 2.55 (s, 6H, CdC(CH3)), 2.52 (s,
6H, CdC(CH3)), 1.81-1.71 (m, 4H, OCH2CH2), 1.30 (br s, 20H,
CH2), and 0.89 (t, 6H, J ) 7 Hz, CH2CH3). 13C NMR (CDCl3,
125 MHz): δ 159.40, 142.87, 142.77, 141.88, 135.14, 131.18,
126.76, 124.07, 114.36, 114.25, 113.20, 113.17, 97.11, 96.88,
95.00, 94.29, 93.53, 67.94, 31.81, 29.34, 29.23, 26.03, 22.65,

1686 J . Org. Chem., Vol. 63, No. 5, 1998
Goldfinger et al.
21.84, 21.57, and 14.08. HREIMS: calcd for C42H52BrIO2
794.2195, observed 794.2189.
6.52 (s, 4H, H17C8OCdCH), 6.45 (s, 4H, H17C8OCdCH), 3.92-
3.83 (m, 12H, OCH2), 3.81 (s, 6H, OCH3), 3.76 (s, 6H, OCH3),
2.20 (s, 12H, CdC(CH3)), 2.19 (s, 12H, CdC(CH3)), 1.82-1.56
(m, 12H, OCH2CH2), 1.28 (br s, 34H, CH2), 1.11 (br s, 34H,
CH2), and 0.88-0.79 (m, 18H, CH2CH3). 13C NMR (CDCl3, 125
MHz): δ 158.56, 158.51, 153.47, 151.27, 150.05, 141.92, 141.88,
139.34, 138.84, 133.73, 133.26, 130.76, 130.11, 123.34, 122.94,
117.03, 116.69, 115.49, 115.38, 113.84, 112.82, 112.76, 112.70,
96.20, 91.44, 91.00, 69.62, 67.79, 67.74, 56.58, 55.82, 31.89,
29.63, 29.42, 29.37, 29.34, 29.31, 29.26, 29.23, 26.03, 21.06,
20.96, and 14.09. LDI-MS: calcd for C126H166O10 1840.69,
observed 1840.32.
4-Br om o-2,5-bis(4-octyloxy-2,6-dim eth ylph en yleth yn yl)-
2′,5′-d im eth oxy-1,1′-bip h en yl (31). A mixture of 29 (166 mg,
0.20 mmol), 2,5-dimethoxyphenylboronic acid (44 mg, 0.09
mmol), Pd(dba)2 (8 mg, 0.014 mmol, 9 mol %), Tl2CO3 (381 mg,
0.81 mmol), and triphenylphosphine (160 mg, 0.61 mmol) in
a Schlenk flask was evacuated and back-filled with argon
thrice. THF (8 mL) and water (1.4 mL) were added, and the
mixture was purged with argon for 30 min. The reaction was
heated to 60 °C for 40 h, cooled, and filtered through a silica
plug with chloroform, and the solvents were removed under
reduced pressure. The resulting sticky yellow solid (350 mg)
was purified by recrystallization from THF-MeOH to give 31
(139 mg, 82%) as a pale yellow solid (mp 100-102 °C). 1H
NMR (CDCl3, 200 MHz): δ 7.82 (s, 1H, CtCCdCH), 7.47 (s,
1H, CtCCdCH), 6.88 (s, 3H, CH3OCdCHCH, CH3OCH), 6.62
(s, 2H, CHdC(CH3)), 6.51 (s, 2H, CHdC(CH3)), 3.95-3.90 (m,
4H, OCH2), 3.77 (s, 3H, OCH3), 3.70 (s, 3H, OCH3), 2.52 (s,
6H, CdCCH3), 2.13 (s, 6H, CdCCH3), 1.81-1.70 (m, 4H,
OCH2CH2), 1.29 (br s, 20H, CH2), and 0.88 (t, 6H, J ) 6 Hz,
CH2CH3). 13C NMR (CDCl3, 125 MHz): δ 159.12, 158.90,
153.51, 151.06, 142.56, 142.18, 139.30, 135.03, 134.11, 129.78,
125.15, 124.93, 123.00, 116.82, 114.90, 113.10, 112.91, 112.66,
95.00, 94.57, 93.63, 92.44, 67.91, 67.85, 56.45, 55.82, 31.80,
29.70, 29.33, 29.32, 29.25, 29.22, 26.03, 26.01, 22.64, 21.56,
20.87, and 14.06. HREIMS: calcd for C50H61BrO4 804.3753,
observed 804.3781.
4-Iod o-2,5-bis(4-octyloxy-2,6-d im eth ylp h en yleth yn yl)-
2′,5′-d im eth oxy-1,1′-bip h en yl (32). A solution of 31 (197 mg,
0.24 mmol, 1 equiv) in THF (25 mL) was cooled to -78 °C and
a 1.4 M solution of n-BuLi in hexane (0.23 mL, 0.32 mmol,
1.3 equiv) was added. After 1 h, a solution of iodine (0.11 g,
0.43 mmol, 1.8 equiv) in THF (10 mL) was added and the
reaction was allowed to warm slowly to room temperature and
stirred for 12 h at room temperature. Excess iodine was
quenched by addition of 2 M KOH (20 mL) and stirring for 30
min. The organic solvents were removed under reduced
pressure, and the granular yellow solid was filtered and
washed with water. Recrystallization from THF-MeOH gave
32 (194 mg, 95%) as an off-white solid (mp 153-154 °C). 1H
NMR (CDCl3, 200 MHz): δ 8.07 (s, 1H, CtCCdCH), 7.44 (s,
1H, CtCCdCH), 6.88 (s, 3H, CH3OCdCHCH, CH3OCH), 6.62
(s, 2H, CHdC(CH3)), 6.51 (s, 2H, CHdC(CH3)), 3.98-3.86 (m,
4H, OCH2), 3.77 (s, 3H, OCH3), 3.70 (s, 3H, OCH3), 2.54 (s,
6H, CdCCH3), 2.13 (s, 6H, CdCCH3), 1.81-1.70 (m, 4H,
OCH2CH2), 1.29 (br s, 20H, CH2), and 0.88 (t, 6H, J ) 6 Hz,
CH2CH3). 13C NMR (CDCl3, 125 MHz): δ 159.08, 153.47,
150.99, 142.64, 142.15, 141.95, 141.30, 140.07, 133.52, 129.81,
129.67, 124.97, 116.74, 114.91, 114.74, 114.05, 113.09, 112.88,
112.60, 98.07, 97.66, 94.29, 92.90, 92.41, 67.89, 67.82, 56.42,
55.81, 31.80, 29.32, 29.22, 26.02, 22.64, 21.85, 20.88, and 14.08.
HREIMS: calcd for C50H61IO4 852.3574, observed 852.3553.
2′,5′,2′′′,5′′′-Tetr akis(4-octyloxy-2,6-dim eth ylph en yleth y-
n yl)-2,5,2′′,5′′,2′′′′,5′′′′-h exam eth oxy[1,1′:4′,1′′: 4′′,1′′′:4′′′, 1′′′′]-
qu in qu ep h en yl (33) was obtained in 84% yield as a colorless
solid (mp 141-143 °C) from 16 and 32 using the same
procedure employed for 31. 1H NMR (CDCl3, 250 MHz): δ
7.62 (s, 2H, CtCCdCH), 7.59 (s, 2H, CtCCdCH), 7.09 (s, 2H,
5,9,16,20-Tetr akis(4-octyloxy-2,6-dim eth ylph en yl)-1,4,8,-
12,15,19-h exa m eth ylbisp h en a n th r o[2,3-a ,h ]a n th r a cen e
(34). To a solution of 33 (43.4 mg, 24 µmol) in CH2Cl2 (15
mL) was added trifluoroacetic acid (0.2 mL, 2.6 mmol, 111
equiv). After 2 h the reaction was diluted with CHCl3 (125
mL) and washed with 2 M KOH (5 × 40 mL). The organic
layer was dried (Na2SO4) and evaporated under reduced
1
pressure to give 43 mg of a brown solid of ∼90% purity by H
NMR. Silica gel chromatography (1:1 hexanes-CHCl3) gave
34 (34 mg, 79%) as a yellow solid (mp 271-273 °C). 1H NMR
(CDCl3, 250 MHz): δ 10.07 (s, 2H), 9.92 (s, 2H), 7.63 (s, 2H),
7.56 (s, 2H), 7.17 (d, 2H, J ) 8.9 Hz), 7.00 (d, 2H, J ) 8.9 Hz),
6.84-6.68 (m, 8H), 4.16 (s, 6H), 4.14-4.00 (m, 12H), 3.41 (s,
6H), 2.29 (s, 6H), 2.25 (s, 6H), 2.06 (s, 6H), 1.89 (s, 6H), 1.33-
1.16 (m, 68H), and 0.93-0.84 (m, 18H). 13C NMR (CDCl3, 125
MHz): δ 157.40, 157.00, 153.72, 151.92, 151.59, 139.39, 138.23,
137.84, 136.49, 135.96, 134.66, 134.29, 134.01, 133.06, 131.33,
130.91, 128.29, 127.53, 127.42, 127.00, 126.14, 125.00, 123.63,
122.29, 112.83, 112.61, 112.39, 112.14, 110.10, 108.86, 74.21,
67.88, 57.14, 56.02, 32.01, 31.91, 31.87, 29.74, 29.69, 29.67,
29.63, 29.56, 29.55, 29.52, 29.46, 29.35, 29.31, 29.26, 26.24,
26.18, 25.71, 22.72, 22.70, 22.69, 21.81, 21.27, 21.18, 20.82,
14.15, and 14.14. LDI-MS: calcd for C126H166O10 1840.69,
observed 1543.
5,9,16,20-Tet r a k is(4-oct yloxy-2,6-d im et h ylp h en yl)-6,-
10,17,21-tetr a iod o-1,4,8,12,15,19-h exa m eth ylbisp h en a n -
th r o[2,3-a ,h ]a n th r a cen e (35). Prepared in 90% yield fol-
lowing the same procedure as was used for 26. 1H NMR
(CDCl3, 250 MHz): δ 10.85 (s, 2H), 10.39 (s, 2H), 7.23 (d, 2H,
J ) 9.1 Hz), 7.02 (d, 2H, J ) 8.9 Hz), 6.76-6.62 (4s, 8H), 4.25
(s, 6H), 4.03-4.00 (m, 12H), 3.34 (s, 6H), 2.29 (s, 6H), 2.00 (s,
6H), 1.94 (s, 6H), 1.85-1.76 (m, 6H), 1.68 (s, 6H), 1.33-1.16
(m, 62H), and 0.93-0.84 (m, 18H).
Ack n ow led gm en t. This work was supported by a
DuPont Young Professor Grant, an Alfred P. Sloan
Fellowship, a Camille Dreyfus Teacher-Scholar award,
and the Office of Naval Research.
Su p p or t in g In for m a t ion Ava ila b le: 1H and 13C NMR
spectra of compounds 10, 12 14, 15, 18, 19, 24-29, and 31-
35 and absortion and emission spectra of compounds 10, 18,
24-27, 33, and 34 (45 pages). This material is contained in
libraries on microfiche, immediately follows this article in the
microfilm version of the journal, and can be ordered from the
ACS; see any current masthead page for ordering information.
H
21C10OCdCH), 7.01-6.91 (m, 6H, MeOCH, MeOCHdCH),
J O9721251