Tetrahedron Letters p. 845 - 848 (1998)
Update date:2022-07-30
Topics:
Baussanne, Isabelle
Royer, Jacques
A new access to enantiopure 4,5-disubstituted pyrrolidin-2-ones has been developed from chiral non racemic α,β-unsaturated-γ-lactams. Conjugate addition of Gilman-type cuprates results in trans addition with excellent diastereoselectivity.
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