Stereoselective synthesis of 4,5-disubstituted pyrrolidin-2-ones by cuprate addition to chiral non racemic α,β-unsaturated-γ-lactams

DOI: 10.1016/S0040-4039(97)10746-8

Source and publish data:

Tetrahedron Letters p. 845 - 848 (1998)

Update date:2022-07-30

Topics:

Authors:

Baussanne, Isabelle

Royer, Jacques

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(97)10746-8

A new access to enantiopure 4,5-disubstituted pyrrolidin-2-ones has been developed from chiral non racemic α,β-unsaturated-γ-lactams. Conjugate addition of Gilman-type cuprates results in trans addition with excellent diastereoselectivity.

Full text of DOI:10.1016/S0040-4039(97)10746-8

Products guided by the article

Product name:(R)-1-((R)-2-Methoxy-1-phenyl-ethyl)-5-((R)-1-trimethylsilanyloxy-propyl)-1,5-dihydro-pyrrol-2-one

Cas No:203984-23-0

R&D Labs maybe for 203984-23-0

Zha Yan

Contact:+86-13914766747

Address:Floors 21&22, Jin Cheng Tower, No. 216 Middle Longpan Road, Nanjing
Jai Radhe Sales

website:http://www.jairadhesales.com

Contact:0091-79-26431096

Address:309 Harikrupa Tower,Nr old Sharda Mandir Char Rasta,Ellisbridge
CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

website:http://www.czyys.com

Contact:0086-519-88802789

Address:No.300,Yanling Middle Road, Changzhou, Jiangsu, China
Xiamen Goodhealth Pharmchem Co., Ltd.

Contact:0086-592-2097683

Address:404R No.2 54# Minzu Rd., Xiamen, China
Henan Harvest Chem Co., Ltd

Contact:+86-371-86058576

Address:NO.32, Jingsan Road, Zhengzhou, China

Relevant to this article

Analysis of 1,4-dimorpholino-7-phenylpyrido[3,4-d]pyridazine (DS-511) and its metabolites in biological specimens. I. Identification of metabolites in rat urine and dog urine and bile

Doi:10.1248/cpb.27.1544
(1979)
Arsenic carbon heterocopic rearrangements. II. Rearrangement of 1-propynyl-1-arsacyclohexadien-4-ones to pyrano- and furanoarsenins

Doi:10.1016/S0040-4039(01)86153-0
(1979)
Synthesis of New Anionic Perhalophenylplatinate(II) Complexes

Doi:10.1081/SIM-120026543
(2003)
1,3-Dimethyl-2-phenylbenzimidazoline as a Novel and Efficient Reagent for Mild Reductive Dehalogenation of α-Halo Carbonyl Compounds and Acid Chlorides

Doi:10.1021/jo00376a064
(1986)
A short asymmetric synthesis of (+)-lyoniresinol dimethyl ether

Doi:10.1021/jo0497454
(2004)
Organic spin clusters. A dendritic-macrocyclic poly(arylmethyl) polyradical with very high spin of S = 10 and its derivatives: Synthesis, magnetic studies, and small-angle neutron scattering

Doi:10.1021/ja031548j
(2004)

Article Doi