Stereoselective synthesis of 4,5-disubstituted pyrrolidin-2-ones by cuprate addition to chiral non racemic α,β-unsaturated-γ-lactams

Article abstract of DOI:10.1016/S0040-4039(97)10746-8

A new access to enantiopure 4,5-disubstituted pyrrolidin-2-ones has been developed from chiral non racemic α,β-unsaturated-γ-lactams. Conjugate addition of Gilman-type cuprates results in trans addition with excellent diastereoselectivity.