Stereoselective synthesis of 4,5-disubstituted pyrrolidin-2-ones by cuprate addition to chiral non racemic α,β-unsaturated-γ-lactams

DOI: 10.1016/S0040-4039(97)10746-8

Source and publish data:

Tetrahedron Letters p. 845 - 848 (1998)

Update date:2022-07-30

Topics:

Authors:

Baussanne, Isabelle

Royer, Jacques

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Article abstract of DOI:10.1016/S0040-4039(97)10746-8

A new access to enantiopure 4,5-disubstituted pyrrolidin-2-ones has been developed from chiral non racemic α,β-unsaturated-γ-lactams. Conjugate addition of Gilman-type cuprates results in trans addition with excellent diastereoselectivity.

Full text of DOI:10.1016/S0040-4039(97)10746-8

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