Novel serine-based linker for the solid-phase synthesis of organic compounds

Article abstract of DOI:10.1016/S0040-4039(97)10618-9

A novel serine-derived linker has been developed that allows phenolic templates to be cleaved from the resin with fluoride ion. The linker is stable to acids such as TFA and bases such as pyrrolidine. The linker should provide utility in multi-step solid phase organic chemistry protocols where both acid and base chemistry is used.