New approaches to the asymmetric synthesis of dipeptide isosteres via β-Lactam Synthon Method

DOI: 10.1016/S0040-4039(97)10677-3

Source and publish data:

Tetrahedron Letters p. 923 - 926 (1998)

Update date:2022-08-03

Topics:

Authors:

Ojima, Iwao

Wang, Hong

Wang, Tao

Ng, Edward W.

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Article abstract of DOI:10.1016/S0040-4039(97)10677-3

New and efficient synthetic routes to dipeptide isosteres with high enantiomeric purity, e.g., hydroxyethylene, dihydroxyethylene and hydroxyethylamine isosteres, have been developed via oxiranes 6 and formyloxazolines 13 derived from N-t-Boc-β-lactams 4.

Full text of DOI:10.1016/S0040-4039(97)10677-3

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