New approaches to the asymmetric synthesis of dipeptide isosteres via β-Lactam Synthon Method

Article abstract of DOI:10.1016/S0040-4039(97)10677-3

New and efficient synthetic routes to dipeptide isosteres with high enantiomeric purity, e.g., hydroxyethylene, dihydroxyethylene and hydroxyethylamine isosteres, have been developed via oxiranes 6 and formyloxazolines 13 derived from N-t-Boc-β-lactams 4.