Tetrahedron Letters p. 1243 - 1246 (1998)
Update date:2022-09-26
Topics:
Reichwein, John F.
Liskamp, Rob M. J.
A convenient approach, featuring a Mitsunobu reaction, is described for the introduction of an alkyl group at a specific amide function of a peptide on the solid phase. This 'site-specific alkylation' procedure is illustrated with an N-ethyl scan of Leu-enkephalin.
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