New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates

DOI: 10.1016/S0960-894X(98)00014-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 295 - 300 (1998)

Update date:2022-08-03

Topics:

Authors:

Mewshaw, Richard E.

Husbands, Morris

Gildersleeve, Elizabeth S.

Webb, Michael B.

Shi, Xiaojie

Mazandarani, Hossein

Cockett, Mark I.

Ochalski, Rafal

Brennan, Julie A.

Abou-Gharbia, Magid

Marquis, Karen

McGaughey, Georgia B.

Coupet, Joseph

Andree, Terrance H.

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Article abstract of DOI:10.1016/S0960-894X(98)00014-6

Described in this report is a systematic study which led to the identification of two new dopamine D₂ partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D₂ partial agonist as well as templates for the future design of novel dopaminergic agents.

Full text of DOI:10.1016/S0960-894X(98)00014-6

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