A convergent approach to cryptophycin 52 analogues: Synthesis and biological evaluation of a novel series of fragment A epoxides and chlorohydrins

DOI: 10.1021/jm0203884

Source and publish data:

Journal of Medicinal Chemistry p. 2985 - 3007 (2003)

Update date:2022-08-04

Topics:

Authors:

Al-Awar, Rima S.

Ray, James E.

Schultz, Richard M.

Andis, Sherri L.

Kennedy, Joseph H.

Moore, Richard E.

Liang, Jian

Golakoti, Trimurtulu

Subbaraju, Gottumukkala V.

Corbett, Thomas H.

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Article abstract of DOI:10.1021/jm0203884

Cryptophycin 52 is a synthetic derivative of Cryptophycin 1, a potent antimicrotubule agent isolated from cyanobacteria. In an effort to increase the potency and water solubility of the molecule, a structure-activity relationship study (SAR) was initiated

Full text of DOI:10.1021/jm0203884

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