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Studies on nonpeptide angiotensin II receptor antagonists. II. Synthesis and biological evaluation of 5H-pyrazolo[1,5-b][1,2,4]triazole derivatives with a C-linked oxygen functional group at the 6-position

DOI: 10.1248/cpb.46.287

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 287 - 293 (1998)

Update date:2022-08-05

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Authors:

Okazaki, ToshioOkazaki, Toshio

Suga, AkiraSuga, Akira

Watanabe, ToshihiroWatanabe, Toshihiro

Kikuchi, KazumiKikuchi, Kazumi

Kurihara, HiroyukiKurihara, Hiroyuki

Shibasaki, MasayukiShibasaki, Masayuki

Fujimori, AkiraFujimori, Akira

Inagaki, OsamuInagaki, Osamu

Yanagisawa, IsaoYanagisawa, Isao

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Article abstract of DOI:10.1248/cpb.46.287

2,7-Diethyl-5H-pyrazolo[1,5-b][1,2,4]triazole derivatives were synthesized and evaluated for activity as angiotensin II receptor antagonists. Replacement of the C-6 hydrogen with C-linked oxygen functional groups led to derivatives with increased in vitro

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Full text of DOI:10.1248/cpb.46.287

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Product name:2,7-diethyl-6-methoxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole

Cas No:204516-41-6

204516-41-6

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