Chemical and Pharmaceutical Bulletin p. 255 - 273 (1998)
Update date:2022-07-31
Topics:
Itoh, Fumio
Nishikimi, Yuji
Hasuoka, Atsushi
Yoshioka, Yoshio
Yukishige, Koichi
Tanida, Seiichi
Aono, Tetsuya
A series of TAN-1511 analogues bearing a non-peptide spacer in place of the Gly-Gly-Gly sequence in the peptide moiety was synthesized, and the effects of these compounds on the proliferation of bone marrow cells in culture and experimental leukocytopenia in mice were examined. The structure- activity relationships obtained were as follows. As the substituent at the 2- position of the 4-thiabeptanoic acid framework, an amino group, methyl group or hydrogen was preferable; as a spacer in place of the Gly-Gly-Gly sequence, a 4-aminobenzoyl or 4-aminomethylbenzoyl group was suitable; and as the fatty acids bonded to the 6,7-dihydroxy groups, C16 fatty acid was best. Compounds 12f, 30d and 30i potently promoted the proliferation of bone marrow cells in culture and the restoration of leukocyte counts in a murine leukocytopenia model.
View MoreTIANJIN FESTO CHEMICAL CO.,LTD(expird)
Contact:86-22-25814570
Address:No.12th,5th Ave.,TEDA,Tianjin,China
shanghai jinshan pharmaceutical Co.,Ltd
Contact:021-57363011,13681638167
Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Contact:+86-571-28186845
Address:Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China
Laizhou City Laiyu Chemical CO.,Ltd
Contact:+86-535-2719337/2719339
Address:Chenggang road zhuyou laizhou City Shangdong China
Weifang Arylchem Chemical Co., LTD
Contact:86-536-5217866
Address:Development Zone, Shouguang, Shandong Province
Doi:10.1039/b103173m
(2001)Doi:10.1002/(SICI)1099-0690(199803)1998:3<453::AID-EJOC453>3.0.CO;2-2
(1998)Doi:10.1039/a708594j
(1998)Doi:10.1016/S0040-4039(98)00628-5
(1998)Doi:10.1055/s-1998-1683
(1998)Doi:10.1002/jlcr.815
(2004)