Chemical and Pharmaceutical Bulletin p. 255 - 273 (1998)
Update date:2022-07-31
Topics:
Itoh, Fumio
Nishikimi, Yuji
Hasuoka, Atsushi
Yoshioka, Yoshio
Yukishige, Koichi
Tanida, Seiichi
Aono, Tetsuya
A series of TAN-1511 analogues bearing a non-peptide spacer in place of the Gly-Gly-Gly sequence in the peptide moiety was synthesized, and the effects of these compounds on the proliferation of bone marrow cells in culture and experimental leukocytopenia in mice were examined. The structure- activity relationships obtained were as follows. As the substituent at the 2- position of the 4-thiabeptanoic acid framework, an amino group, methyl group or hydrogen was preferable; as a spacer in place of the Gly-Gly-Gly sequence, a 4-aminobenzoyl or 4-aminomethylbenzoyl group was suitable; and as the fatty acids bonded to the 6,7-dihydroxy groups, C16 fatty acid was best. Compounds 12f, 30d and 30i potently promoted the proliferation of bone marrow cells in culture and the restoration of leukocyte counts in a murine leukocytopenia model.
View Morewebsite:http://www.mingchem.com/en/index
Contact:0519-85170101-802
Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
Contact:+49-9398-993127
Address:Untertorstr. 27
Contact:86-512-87182055
Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
Liaoning Yufeng Chemical Co.,Ltd.
Contact:86-0419-3418888
Address:The metallurgical industrial zone,shoushan town, Liaoyang, Liaoning, China
Changzhou Qidi Chemical Co., Ltd
website:http://www.czqdhg.com/
Contact:86-519-83382137
Address:128-1-16# HuaYuan Street,Hutang Town,Wujin District,Changzhou City,P.R.China.
Doi:10.1039/b103173m
(2001)Doi:10.1002/(SICI)1099-0690(199803)1998:3<453::AID-EJOC453>3.0.CO;2-2
(1998)Doi:10.1039/a708594j
(1998)Doi:10.1016/S0040-4039(98)00628-5
(1998)Doi:10.1055/s-1998-1683
(1998)Doi:10.1002/jlcr.815
(2004)
