Tetrahedron p. 3113 - 3124 (1998)
Update date:2022-07-30
Topics:
Chao, Qi
Zhang, Jianzhong
Pickering, Lea
Jahnke, Tamera S.
Nair, Vasu
A novel class of dideoxynucleosides containing a bicyclic sugar moiety, structurally related to the natural griseolic acids, was synthesized starting from the stereochemically defined compound, 1,4:3,6-dianhydro-D-glucitol. The key intermediate in the synthesis was a [3.3.0] fused bicyclic glycal. Glycosylation of this compound with nucleobase proceeded both regiospecifically and stereospecifically in the presence of an auxiliary agent, N-iodosuccinamide. Changes in stereochemistry during the synthesis was monitored by optical rotation data and confirmed by both 1D and 2D NMR experiments. The synthetic approach described possesses general usefulness.
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Doi:10.1016/S0960-894X(98)00033-X
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(1998)