Organic Letters p. 5157 - 5162 (2020)
Update date:2022-08-03
Topics:
Gueret, Robin
Pelinski, Lydie
Bousquet, Till
Sauthier, Mathieu
Ferey, Vincent
Bigot, Antony
Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl piperazines. The iridium-based complex [Ir(ppy)2(dtbpy)]PF6 and carbazolyl dicyanobenzene 4CzIPN were found to be the photocatalysts of choice to efficiently perform the transformation under mild conditions, whether in batch or in continuous mode.
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