A phosphorus-containing chiral amidine ligand for asymmetric reactions: Enantioselective Pd-catalyzed allylic alkylation

Article abstract of DOI:10.1016/S0957-4166(97)00482-5

Phosphorus-containing amidine 7 was prepared through several steps from L-valine 1. The new ligand for asymmetric reactions was evaluated in the palladium-catalyzed allylic alkylation of 1,3-diphenylprop-2-enyl acetate and pivalate 8a,b with the nucleophile derived from dimethyl malonate as a preliminary study. Excellent levels of asymmetric induction up to 95% e.e. were achieved along with an efficient conversion.