Bioorganic and Medicinal Chemistry Letters p. 2975 - 2978 (2001)
Update date:2022-08-03
Topics:
Levin
Chen
Du
Nelson
Wehr
DiJoseph
Killar
Skala
Sung
Sharr
Roth
Jin
Cowling
Di
Sherman
Xu
March
Mohler
Black
Skotnicki
Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13.
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