Bioorganic and Medicinal Chemistry Letters p. 2887 - 2892 (1999)
Update date:2022-08-03
Topics:
Martin, Fionna M.
Beckett, R. Paul
Bellamy, Claire L.
Courtney, Paul F.
Davies, Stephen J.
Drummond, Alan H.
Dodd, Rory
Pratt, Lisa M.
Patel, Sanjay R.
Ricketts, Michelle L.
Todd, Richard S.
Tuffnell, Andrew R.
Ward, John W. S.
Whittaker, Mark
Novel sulfonamide matrix metalloproteinase inhibitors of general formula (9) were synthesised by a route involving a stereoselective conjugate addition reaction. Enzyme selectivity was found to be dependant on the nature of the sulfonamide substituents. Compounds (9f, 9q) are potent selective collagenase inhibitors with good oral bioavailability.
puyang hongda shengdao new material co.,ltd.
Contact:+86-393- 4896278
Address:No.29 East Zhongyuan Road
Chengdu Push Bio-technology Co., Ltd
Contact:86-28-85370565
Address:No.8 Wuke West Second Road, Wuhou
Shanghai Mintchem Development ., Ltd
Contact:0086 21 5190 8570
Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
Huangshi Meifeng Chemical Co.,ltd.
Contact:+86-714-6516706
Address:1941-4-3#,Hubin Avenue,Huangshi,Hubei,China
Yingkou Sanzheng Organic Chemical Co. Ltd.
Contact:+86-417-3638818
Address:25 Gengxinli Village, Daqing Road, Yingkou, Liaoning, China
Doi:10.1016/S0040-4039(01)97954-7
(1970)Doi:10.1016/j.ica.2019.05.030
(2019)Doi:10.1016/S0040-4020(98)00175-6
(1998)Doi:10.1016/S0040-4039(97)01411-1
(1997)Doi:10.1016/j.poly.2020.114421
(2020)Doi:10.1016/S0040-4039(01)00551-2
(2001)
