Bioorganic and Medicinal Chemistry Letters p. 2887 - 2892 (1999)
Update date:2022-08-03
Topics:
Martin, Fionna M.
Beckett, R. Paul
Bellamy, Claire L.
Courtney, Paul F.
Davies, Stephen J.
Drummond, Alan H.
Dodd, Rory
Pratt, Lisa M.
Patel, Sanjay R.
Ricketts, Michelle L.
Todd, Richard S.
Tuffnell, Andrew R.
Ward, John W. S.
Whittaker, Mark
Novel sulfonamide matrix metalloproteinase inhibitors of general formula (9) were synthesised by a route involving a stereoselective conjugate addition reaction. Enzyme selectivity was found to be dependant on the nature of the sulfonamide substituents. Compounds (9f, 9q) are potent selective collagenase inhibitors with good oral bioavailability.
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