Bioorganic and Medicinal Chemistry Letters p. 711 - 714 (1998)
Update date:2022-08-05
Topics:
Qiao, Lixin
Kozikowski, Alan P.
Olivera, Ana
Spiegel, Sarah
The synthesis of a photolyzable sphingosine 1-phosphate derivative is reported via the reaction of N-(tert-butoxycarbonyl)-2-N,3-O-isopropylidenesphingosine 7 and bis(α-methyl-o-nitrobenzyl) N,N-diisopropylphosphoramidite. Stimulation of DNA synthesis upon illumination of caged SPP-loaded cells is also described.
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