Diastereoselective deuteration of (Z)-α,β-dehydrotryptophanyl- containing biological peptides controlled by chiral rhodium catalysts

Article abstract of DOI:10.1016/S0040-4039(98)00377-3

The regio- and stereoselective labelling (₂H, ₃H) of tryptophanyl containing biological peptides catalysed by chiral rhodium complexes is described. The Δ(z)Trp-residue is directly produced in the peptide by a catalytic process, invo