Chemical and Pharmaceutical Bulletin p. 711 - 713 (1995)
Update date:2022-07-31
Topics:
Miyashita
Nishimoto
Ishino
Obika
Imanishi
Both C-4 stereoisomers of novel Hantzsch-type 4-aryl- and 4-methyl-1,4-dihydropyridines 3 having a p-tolylsulfinyl group at C-5 were efficiently synthesized in optically pure forms starting from the α-sulfinyl enones 6 which could be easily obtained from (-)-menthyl (S)-p-tolylsulfinate (4). The stereochemistry at C-4 was found to be largely responsible for the biological activities as calcium channel antagonists of these compounds.
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