Functionalization of nucleoside analogs: Regiospecific conversion of 4'- hydroxyl groups to thioesters and deoxygenation of 3'-hydroxyl groups

Article abstract of DOI:10.1080/07328319808003461

Nucleoside analogs 3a-e were conveniently functionalized by regiospecifically converting 4'-hydroxyl groups to thioesters 4a-e (>90% yield) and reducing 3'-hydroxyl groups to give building blocks 2a-e in 85- 90% yields.

Full text of DOI:10.1080/07328319808003461

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Functionaleation of Nucleoside Analogs:
Regiospecific Conversion of 4″-Hydroxyl
Groups to Thioesters and Deoxygenation
of 3′-Hydroxyl Groups
Zhen Huang a & Steven A. Benner b
a Department of Chemistry , University of Florida , Gainesville, FL,
32611
b Department of Molecular Biology , Massachusetts General Hospital ,
Boston, MA, 02114
Published online: 21 Aug 2006.
To cite this article: Zhen Huang & Steven A. Benner (1998) Functionaleation of Nucleoside Analogs:
Regiospecific Conversion of 4″-Hydroxyl Groups to Thioesters and Deoxygenation of 3′-Hydroxyl
Groups, Nucleosides and Nucleotides, 17:5, 895-899, DOI: 10.1080/07328319808003461
To link to this article: http://dx.doi.org/10.1080/07328319808003461
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