Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors

Article abstract of DOI:10.1016/S0960-894X(97)00333-8

The structure-activity relationships (SAR) for a new class of potent inhibitors (1) of influenza neuraminidase are described. Systematic modifications of substituents at the C-3, C-4, and C-5 positions of the carbocyclic ring were performed to establish fundamental SAR to assist in the design of potent inhibitors with activity against both of influenza A and B viruses.