Bioorganic and Medicinal Chemistry Letters p. 1837 - 1842 (1997)
Update date:2022-08-03
Topics:
Williams, Matthew A.
Lew, Willard
Mendel, Dirk B.
Tai, Chun Y.
Escarpe, Paul A.
Laver, W. Graeme
Stevens, Raymond C.
Kim, Choung U.
The structure-activity relationships (SAR) for a new class of potent inhibitors (1) of influenza neuraminidase are described. Systematic modifications of substituents at the C-3, C-4, and C-5 positions of the carbocyclic ring were performed to establish fundamental SAR to assist in the design of potent inhibitors with activity against both of influenza A and B viruses.
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