Annonaceous acetogenins: Preparation of new methoxy substituted THF synthons from D-glucose

Article abstract of DOI:10.1016/S0040-4020(98)00336-6

In connection with the synthesis of cytotoxic annonaceous acetogenin analogs, enantiomerically pure threo (and erythro)-trans THF synthons have been prepared from D-glucose. These synthons are characterized by the presence of two methoxy (or hydroxy) groups in the THF ring, each in a cis configuration with respect to the vicinal side chain.